Assessment of abdominal aortic calcification by computed tomography for prediction of latent left ventricular stiffness and future cardiovascular risk in pre-dialysis patients with chronic kidney disease: A single center cross-sectional study
| Autor: | Susumu Suzuki, Toyoaki Murohara, Yoshinari Yasuda, Ryota Morimoto, Kenji Furusawa, Yosuke Tatami, Takahiro Okumura, Kyosuke Takeshita |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty left ventricular diastolic dysfunction Heart Ventricles education Renal function Asymptomatic Ventricular Dysfunction Left 03 medical and health sciences 0302 clinical medicine Risk Factors Diabetes mellitus Internal medicine medicine Humans Aorta Abdominal Prospective Studies Renal Insufficiency Chronic Vascular Calcification Aged Aged 80 and over cardiorenal syndrome Receiver operating characteristic business.industry Hazard ratio General Medicine Middle Aged Prognosis medicine.disease abdominal aortic calcification Confidence interval Cross-Sectional Studies ROC Curve Echocardiography Heart failure Cardiology Female 030211 gastroenterology & hepatology medicine.symptom Tomography X-Ray Computed business chronic kidney disease Research Paper Kidney disease |
| Zdroj: | International Journal of Medical Sciences |
| ISSN: | 1449-1907 |
| Popis: | Introduction: There is general interest in finding clinical markers for left ventricular diastolic dysfunction (LVDD), a major cause of cardiorenal syndrome leading to heart failure in chronic kidney disease (CKD) patients. The aim was to assess the utility of computed tomography (CT)-based abdominal aortic calcification (AAC) for the prediction of LVDD and prognosis of asymptomatic pre-dialysis CKD patients. Materials and methods: We prospectively evaluated 218 pre-dialysis CKD patients [median estimated glomerular filtration rate (eGFR); 40.9 mL/min/1.73m²]. Non-contrast CT scan and echocardiography were performed to determine the aortic calcification index (ACI) as a semi-quantitative measure of AAC. Results: The median ACI was 11.4. AAC and LVDD were diagnosed in 193 patients (89%) and 75 patients (34%), respectively. Using receiver operating characteristic curve analysis for the estimation of LVDD, ACI of 20 showed optimal sensitivity (52.0%) and specificity (62.8 %) (AUC = 0.664, p < .001). High ACI group included more patients with LVDD-related factors, such as old age, hypertension, diabetes, and more severe CKD. LVDD was significantly more common in patients with high ACI group [39 (50%) and 36 (26%), respectively, p |
| Databáze: | OpenAIRE |
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