Brain SPECT findings of anosognosia in Alzheimer's disease
| Autor: | Stavros J. Baloyannis, Athanasios S Dimitriadis, Thomas Tegos, Vasiliki Costa, Fereshteh Sedaghat, Eleni Dedousi, Ioannis S. Baloyannis |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Prefrontal Cortex Temporal lobe Alzheimer Disease Internal medicine Parietal Lobe medicine Dementia Humans Prefrontal cortex Aged Temporal cortex Aged 80 and over Cerebral Cortex Tomography Emission-Computed Single-Photon business.industry General Neuroscience Anosognosia Parietal lobe General Medicine medicine.disease Self Concept Temporal Lobe Psychiatry and Mental health Clinical Psychology Cerebral blood flow Cerebrovascular Circulation Cardiology Agnosia Female Geriatrics and Gerontology Alzheimer's disease business |
| Zdroj: | Journal of Alzheimer's disease : JAD. 21(2) |
| ISSN: | 1875-8908 |
| Popis: | Anosognosia is a common symptom of dementia. The aim of this study was to evaluate the contribution of different regions of the brain to anosognosia in Alzheimer's disease (AD) brains using single photon emission computed tomography (SPECT). Forty-two patients with AD were included in this study. After clinical interviews with the patients and their relatives, the patients were divided into two groups: Anosognosia and No-anosognosia. The patients were studied regarding the severity of dementia. They underwent SPECT with HMPAO and regional cerebral blood flow (rCBF) was measured. Regional CBF significantly differed between Anosognosia and No-anosognosia groups in right prefrontal (P < or = 0.02), right inferior parietal (P < or = 0.00), and right (P < or = 0.01) and left (P < or = 0.01) medial temporal cortex. There was a significant correlation between the severity of dementia and rCBF in medial temporal regions. When comparisons were made between mild and moderate stages separately, the 'right inferior parietal region' was the common region which showed hypoperfusion in both anosognosia subgroups. We conclude that anosognosia may be a reflection of functional impairment in right prefrontal, right frontal and especially right inferior parietal regions in AD. |
| Databáze: | OpenAIRE |
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