Plasma renin activity in heart failure-prone SHHF/Mcc-facp rats

Autor: R. B. Dunn, Bethany J. Holycross, B. M. Summers, Sylvia A. McCune
Rok vydání: 1997
Předmět:
Male
medicine.medical_specialty
Aging
animal structures
Heart disease
Physiology
medicine.drug_class
Rats
Inbred WF
Blood Pressure
urologic and male genital diseases
Plasma renin activity
Rats
Sprague-Dawley
chemistry.chemical_compound
Atrial natriuretic peptide
Species Specificity
Physiology (medical)
Internal medicine
Rats
Inbred SHR
Renin–angiotensin system
Renin
medicine
Animals
Aldosterone
Heart Failure
Blood Volume
business.industry
Rats
Inbred Strains
Organ Size
medicine.disease
female genital diseases and pregnancy complications
Rats
Blood pressure
Endocrinology
chemistry
Mineralocorticoid
Heart failure
Hypertension
Regression Analysis
Female
Disease Susceptibility
Cardiology and Cardiovascular Medicine
business
hormones
hormone substitutes
and hormone antagonists
Atrial Natriuretic Factor
circulatory and respiratory physiology
Zdroj: The American journal of physiology. 273(1 Pt 2)
ISSN: 0002-9513
Popis: Plasma renin activity (PRA) increases during heart failure; however, PRA is altered by drug therapy, and it is difficult to study the natural progression of elevated PRA in humans and the possible factors that contribute to its rise. This study evaluated PRA in a drug-naive hypertensive rat model (SHHF/Mcc-facp) that has a genetic program resulting in heart failure (HF). Mean arterial blood pressure and PRA were determined and correlated to heart weight index in conscious normotensive, spontaneously hypertensive rats and HF rats of various ages. PRA, atrial natriuretic peptide, and aldosterone levels progressively increase with age in male HF rats. PRA and blood pressure are independently correlated to cardiac hypertrophy in male HF rats. Atrial natriuretic peptide was elevated in spontaneously hypertensive compared with normotensive rats. Female HF rats have elevated PRA, but the increase is temporally delayed compared with that in male HF rats. Hypertension, PRA, and male gender are independent factors contributing to cardiac hypertrophy and heart failure in the HF model. The HF rat model may prove useful in determining the contribution of these factors in the progression from cardiac hypertrophy to heart failure.
Databáze: OpenAIRE
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