Inhibition of sodium‐glucose cotransporter 2 ameliorates renal injury in a novel medaka model of nonalcoholic steatohepatitis‐related kidney disease

Autor: Kenya Kamimura, Hiroshi Nishina, Atsushi Kimura, Ryo Goto, Masayoshi Ko, Yusuke Niwa, Shuji Terai, Takuro Nagoya, Yoko Shinagawa-Kobayashi, Norihiro Sakai
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Oryzias
medicine.disease_cause
0302 clinical medicine
renal disease
Glucosides
Non-alcoholic Fatty Liver Disease
Macrophage
lcsh:QH301-705.5
Research Articles
Kidney
NASH
SGLT2 inhibitor
medicine.anatomical_structure
Oryzias latipes
030220 oncology & carcinogenesis
Sodium/Glucose Cotransporter 2
Kidney Diseases
SGLT2 Inhibitor
Research Article
medicine.medical_specialty
kidney
Diet
High-Fat
digestive system
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
Glutamate Plasma Membrane Transport Proteins
Renal injury
Internal medicine
medicine
Animals
Hypoglycemic Agents
Benzhydryl Compounds
Sodium-Glucose Transporter 2 Inhibitors
business.industry
Sodium
nutritional and metabolic diseases
medicine.disease
digestive system diseases
Disease Models
Animal
030104 developmental biology
Endocrinology
Glucose
lcsh:Biology (General)
Diabetes Mellitus
Type 2
business
Cotransporter
medaka disease model
Oxidative stress
Kidney disease
Zdroj: FEBS Open Bio
FEBS Open Bio, Vol 9, Iss 12, Pp 2016-2024 (2019)
ISSN: 2211-5463
Popis: The effect of sodium‐glucose cotransporter 2 inhibitor (SGLT2I) on nonalcoholic steatohepatitis (NASH) has been reported, but there are few studies on its effect on NASH‐related renal injury. In this study, we examined the effect of SGLT2I using a novel medaka fish model of NASH‐related kidney disease, which was developed by feeding the d‐rR/Tokyo strain a high‐fat diet. SGLT2I was administered by dissolving it in water of the feeding tank. SGLT2I ameliorates macrophage accumulation and oxidative stress and maintained mitochondrial function in the kidney. The results demonstrate the effect of SGLT2I on NASH‐related renal injury and the usefulness of this novel animal model for research into NASH‐related complications.
Here, we demonstrate that the highly specific sodium‐glucose cotransporter 2 inhibitor (SGLT2I) prevented the progression of nonalcoholic steatohepatitis (NASH)‐related renal injury in a medaka fish model of NASH‐related kidney disease. SGLT2I ameliorates oxidative stress and macrophage accumulation and maintained mitochondrial function in renal tubules.
Databáze: OpenAIRE
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