Inhibition of sodium‐glucose cotransporter 2 ameliorates renal injury in a novel medaka model of nonalcoholic steatohepatitis‐related kidney disease
Autor: | Kenya Kamimura, Hiroshi Nishina, Atsushi Kimura, Ryo Goto, Masayoshi Ko, Yusuke Niwa, Shuji Terai, Takuro Nagoya, Yoko Shinagawa-Kobayashi, Norihiro Sakai |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Oryzias medicine.disease_cause 0302 clinical medicine renal disease Glucosides Non-alcoholic Fatty Liver Disease Macrophage lcsh:QH301-705.5 Research Articles Kidney NASH SGLT2 inhibitor medicine.anatomical_structure Oryzias latipes 030220 oncology & carcinogenesis Sodium/Glucose Cotransporter 2 Kidney Diseases SGLT2 Inhibitor Research Article medicine.medical_specialty kidney Diet High-Fat digestive system General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Glutamate Plasma Membrane Transport Proteins Renal injury Internal medicine medicine Animals Hypoglycemic Agents Benzhydryl Compounds Sodium-Glucose Transporter 2 Inhibitors business.industry Sodium nutritional and metabolic diseases medicine.disease digestive system diseases Disease Models Animal 030104 developmental biology Endocrinology Glucose lcsh:Biology (General) Diabetes Mellitus Type 2 business Cotransporter medaka disease model Oxidative stress Kidney disease |
Zdroj: | FEBS Open Bio FEBS Open Bio, Vol 9, Iss 12, Pp 2016-2024 (2019) |
ISSN: | 2211-5463 |
Popis: | The effect of sodium‐glucose cotransporter 2 inhibitor (SGLT2I) on nonalcoholic steatohepatitis (NASH) has been reported, but there are few studies on its effect on NASH‐related renal injury. In this study, we examined the effect of SGLT2I using a novel medaka fish model of NASH‐related kidney disease, which was developed by feeding the d‐rR/Tokyo strain a high‐fat diet. SGLT2I was administered by dissolving it in water of the feeding tank. SGLT2I ameliorates macrophage accumulation and oxidative stress and maintained mitochondrial function in the kidney. The results demonstrate the effect of SGLT2I on NASH‐related renal injury and the usefulness of this novel animal model for research into NASH‐related complications. Here, we demonstrate that the highly specific sodium‐glucose cotransporter 2 inhibitor (SGLT2I) prevented the progression of nonalcoholic steatohepatitis (NASH)‐related renal injury in a medaka fish model of NASH‐related kidney disease. SGLT2I ameliorates oxidative stress and macrophage accumulation and maintained mitochondrial function in renal tubules. |
Databáze: | OpenAIRE |
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