An outpatient approach to female sterilization with methylcyanoacrylate
| Autor: | Hans Zinser, Lee R Bolduc, Gastavo Argueta Rivas, Ralph M. Richart, Per Agnar Nilsen, Robert S. Neuwirth, Gerd Eldering, Jean Cohen, Hans Baur, Thomas Stevenson |
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| Rok vydání: | 1980 |
| Předmět: |
Clinical Trials as Topic
medicine.medical_specialty Hysterectomy medicine.diagnostic_test Sterilization Tubal business.industry Genitourinary system Female sterilization medicine.medical_treatment Obstetrics and Gynecology Methylcyanoacrylate Surgery Clinical research Ambulatory Ambulatory Care Humans Medicine Outpatient clinic Female Tissue Adhesives Cyanoacrylates Hysterosalpingography business |
| Zdroj: | American Journal of Obstetrics and Gynecology. 136:951-956 |
| ISSN: | 0002-9378 |
| Popis: | MCA is a tissue adhesive which can be delivered transcervically to the Fallopian tubes by means of the FEMCEPT device. In the patients treated with this system, both prior to hysterectomy and on an ambulatory basis, there have been no significant complications or side effects. In the most recent series of ambulatory patients treated with the REMCEPT-MCA system, the bilateral tubal closure rate was 78%.Clinical trials of methylcyanoacrylate (MCA), a tissue adhesive injected to occlude fallopian tubes for tubal sterilization, were conducted in ambulatory patients and are presented. 3 small series of patients are described; most received .4-ml injections, but 23 of the 131 total subjects received .6-ml injections. Outcome was determined by hysterosalpingography. Bilateral closure rate after 1 treatment in series 1 (n=28) was 64%. In the 2nd series the bilateral closure rate was 54% after 1 injection; after a 2nd injection in the 2nd series, the rate was 78%, but overall the closure rate for this group after 2 injections was 65% (n=102). In the 3rd series, bilateral closure rate was 78% after 1 injection; this series used .6-ml injections and represents a dramatic improvement over the preceding series. Complications include pain at site of injection, mild to moderate cramping, and transient vagal reaction. The procedure takes 5 minutes or less. 2 uterine pregnancies have occurred to date, and no ectopic pregnancies were reported. MCA is a low-viscosity fluid in a monomeric form which rapidly polymerizes when placed in contact with body fluids. |
| Databáze: | OpenAIRE |
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