Atrazine-induced degranulation of thyroid mast cells in peripubertal and adult rats
| Autor: | Ivana Koledin, Milica Matavulj, Vesna Rajkovic, Renata Kovac |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
QH301-705.5 Population Stereology Biology General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Paracrine signalling Internal medicine medicine Atrazine Biology (General) education education.field_of_study General Immunology and Microbiology thyroid gland General Neuroscience Thyroid Degranulation Mast cell medicine.anatomical_structure Endocrinology chemistry stereology General Agricultural and Biological Sciences Reproductive toxicity mast cell atrazine |
| Zdroj: | Open Life Sciences, Vol 7, Iss 1, Pp 25-32 (2012) |
| ISSN: | 2391-5412 |
| Popis: | Atrazine is a commonly used pesticide in the US and the non-EU countries. It is classified as an endocrine-disrupting chemical and is well-known for its reproductive toxicity in mammals and lower vertebrates. The study on atrazine effects on thyroid mast cells was performed on juvenile/peripubertal and adult male Wistar rats orally gavaged with atrazine at doses of 50 mg/kg of body weight (bw) or 200 mg/kg bw. In order to visualize the mast cell population within the thyroid gland, a histochemical staining method of toluidine blue was used. The results of the histological evaluation demonstrated a prominent increase in mast cell degranulation in both age groups and at both atrazine doses. According to the stereological analysis, a statistically significant decrease in the mast cell volume density in the young rats exposed to a higher dose of atrazine was found when compared to the corresponding control. The numerical density of mast cells significantly decreased in a higher-dose atrazine treated adults in comparison to the control. The obtained data suggest that atrazine-affected mast cells would probably have a consequent influence on thyroid follicular cells and/or thyroid microvasculature via paracrine action of released mediators, but might also be involved in already suggested thyroid cancerogenesis. |
| Databáze: | OpenAIRE |
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