Effects of Repeated Intravitreal Aflibercept Injection on the Corneal Endothelium in Patients With Age-Related Macular Degeneration: Outcomes From the RE-VIEW Study
| Autor: | Jane Caty Cook, Namrata Saroj, Michael C. Singer, Harry J. Menegay, Beth Ann Benetz, David S. Boyer, Yenchieh Cheng, Karen W. Chu, Hadi Moini, Robert Vitti, Constantinos P. Tsipis, Jonathan H. Lass, Erickson Kristine A, Yuhwen Soo |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Corneal endothelium medicine.medical_specialty Visual acuity genetic structures Endothelium Recombinant Fusion Proteins Visual Acuity Angiogenesis Inhibitors Cell Count Macular Degeneration 03 medical and health sciences 0302 clinical medicine Ophthalmology medicine Humans In patient 030212 general & internal medicine Aged business.industry Aflibercept Injection Endothelium Corneal Macular degeneration medicine.disease eye diseases Receptors Vascular Endothelial Growth Factor medicine.anatomical_structure Multicenter study Intravitreal Injections Toxicity 030221 ophthalmology & optometry Female sense organs medicine.symptom business |
| Zdroj: | Cornea. 37:596-601 |
| ISSN: | 0277-3740 |
| Popis: | Purpose The effects of repeated intravitreal aflibercept injection (IAI) on the corneal endothelium were studied in patients with unilateral neovascular age-related macular degeneration. Methods RE-VIEW was a phase 4, open-label, single-arm, multicenter study. Patients received IAI every 8 weeks after 3 monthly doses. Slit-lamp biomicroscopy was performed at all study visits. The central corneal endothelial health was evaluated by specular microscopy in the treated versus untreated fellow eyes at baseline and weeks 24 and 52. Results No slit-lamp abnormalities were noted in 154 enrolled patients (eyes). Baseline versus 52-week mean (±SD) endothelial morphometric values (n = 118) for the treated versus untreated fellow eyes were respectively as follows: endothelial cell density was 2410 ± 364 versus 2388 ± 384 cells/mm at baseline and remained unchanged at 2401 ± 353 versus 2376 ± 364 cells/mm at 52 weeks (P = 0.87); the coefficient of variation was 33.5 ± 4.4% versus 34.0 ± 5.0% at baseline and remained unchanged at 34.2 ± 4.7% versus 34.1 ± 4.9% at 52 weeks (P = 0.18); the percentage of hexagonal cells was 59.5 ± 5.8% versus 59.6 ± 6.4% at baseline and remained unchanged at 59.5 ± 6.0% versus 59.5 ± 5.8% at 52 weeks (P = 0.96). Conclusions Repeated IAI for 52 weeks had no apparent corneal endothelial toxicity noted on specular microscopy in patients treated for neovascular age-related macular degeneration. |
| Databáze: | OpenAIRE |
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