2-18F-fluoro-2-deoxyglucose positron emission tomography in delirium
| Autor: | Gideon A. Caplan, Lucy Haggstrom, Eva A. Wegner, Julia A. Nelson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Cerebral metabolism Neuropsychological Tests behavioral disciplines and activities Gyrus Cinguli 03 medical and health sciences 0302 clinical medicine Functional neuroimaging Fluorodeoxyglucose F18 mental disorders medicine Image Processing Computer-Assisted Humans Attention 030212 general & internal medicine Prospective Studies Aged Aged 80 and over medicine.diagnostic_test Deoxyglucose Delirium Original Articles Magnetic Resonance Imaging nervous system diseases Glucose Neurology Positron emission tomography Anesthesia Positron-Emission Tomography Female Neurology (clinical) medicine.symptom Radiopharmaceuticals Cardiology and Cardiovascular Medicine Psychology 030217 neurology & neurosurgery |
| Popis: | Delirium is a common, serious, yet poorly understood syndrome. Growing evidence suggests cerebral metabolism is fundamentally disturbed; however, it has not been investigated using 2-18F-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) in delirium. This prospective study thus explored FDG PET patterns of cerebral glucose metabolism in older inpatients with delirium. A particular emphasis was on the posterior cingulate cortex (PCC), a key region for attention, which is a central feature of delirium. Delirium scans were compared with post-delirium scans using visual analysis and semi-quantitative analysis with NeuroQ; 13 participants (8 female, median 84 y) were scanned during delirium, and 6 scanned again after resolution. On visual analysis, cortical hypometabolism was evident in all participants during delirium (13/13), and improved with delirium resolution (6/6). Using NeuroQ, glucose metabolism was higher post-delirium in the whole brain and bilateral PCC compared to during delirium ( p |
| Databáze: | OpenAIRE |
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