Ameliorative effects of acetyl-L-carnitine on corpus callosum and functional recovery in demyelinated mouse model
| Autor: | Sanaz, Gharighnia, Ameneh, Omidi, Iraj, Ragerdi Kashani, Mohammad Reza, Sepand, Shahram, Pour Beiranvand |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | International Journal of Neuroscience. :1-11 |
| ISSN: | 1543-5245 0020-7454 |
| Popis: | Multiple sclerosis (MS) is the most common chronic inflammatory demyelinating disease of the central nervous system. Oxidative stressThirty male C57BL/6 mice were divided into three groups. The control animals received a normal diet. The CPZ and CPZ + ALC groups were fed with a 0.2% cuprizone diet for 12 weeks. In the CPZ + ALC group, animals received ALC (300 mg/kg/day) from the 10BWT data showed ALC significantly improves balance and gait in the demyelinating mouse model. Histological staining represented ALC effectively increased remyelination in the CC. Biochemical evaluations demonstrated ALC decreased the malondialdehyde level with a parallel increase in the reduced glutathione and catalase activity levels in the CC. Molecular analysis revealed that ALC significantly increased the expression of oligodendrocyte transcription-2 (Olig-2) and Poly lipoproteins (Plp) genes in the CC.ALC improved balance and motor coordination in the demyelinated mouse model. It may be by reducing the levels of free radicals and increasing the expression of Olig-2 and Plp as myelin-related genes. |
| Databáze: | OpenAIRE |
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