Chiral separation by a monofunctionalized cyclodextrin derivative: From selector to permethyl-β-cyclodextrin bonded stationary phase
| Autor: | Júlia Visy, Krisztina Németh, Gábor Tárkányi, Miklós Simonyi, Laszlo Jicsinszky, Orsolya Toke, Róbert Iványi, Julianna Szemán, Gábor Varga, Lajos Szente |
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| Rok vydání: | 2010 |
| Předmět: |
Silicon
Magnetic Resonance Spectroscopy Clinical Biochemistry Analytical chemistry Pharmaceutical Science High-performance liquid chromatography Analytical Chemistry Inclusion compound chemistry.chemical_compound Capillary electrophoresis Coumarins Drug Discovery Magic angle spinning Chromatography High Pressure Liquid Spectroscopy chemistry.chemical_classification Carbon Isotopes Nitrogen Isotopes Cyclodextrin beta-Cyclodextrins Stereoisomerism Combinatorial chemistry Chiral column chromatography chemistry Solid-state nuclear magnetic resonance Warfarin Lactone |
| Zdroj: | Journal of Pharmaceutical and Biomedical Analysis. 51:84-89 |
| ISSN: | 0731-7085 |
| DOI: | 10.1016/j.jpba.2009.08.009 |
| Popis: | Preparation of (6-monoureido-6-monodeoxy) permethylated beta-cyclodextrin bonded chiral stationary phase from permethylated 6-monoamino-6-monodeoxy-beta-cyclodextrin is described. The optimized chiral stationary phase was evaluated by using HPLC separation of racemates of coumarin derivatives. Column characterization was performed by solid-state (13)C, (15)N, (29)Si NMR using cross-polarization at the magic angle spinning. The development process was supported by CE experiments where the complex formation between cyclodextrins and warfarin was investigated. The results demonstrate good enantio-discrimination for coumarin derivatives. |
| Databáze: | OpenAIRE |
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