Specificity and sensitivity of the assay for elastin-derived peptides in chronic obstructive pulmonary disease
| Autor: | George Weinbaum, Mitchell Glass, Umberto Kucich, Stephen Akers, Glenn D. Rosen, Joel Rosenbloom, Philip Kimbel, Morris Swartz |
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| Rok vydání: | 1992 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male medicine.medical_specialty Pathology Inflammatory arthritis Enzyme-Linked Immunosorbent Assay Gastroenterology Asymptomatic Sensitivity and Specificity Pathogenesis Risk Factors Internal medicine medicine Humans Lung Diseases Obstructive Asthma Aged COPD Lung business.industry Respiratory disease Smoking Middle Aged medicine.disease respiratory tract diseases Elastin Pneumonia medicine.anatomical_structure ROC Curve Female medicine.symptom business |
| Zdroj: | The American review of respiratory disease. 145(5) |
| ISSN: | 0003-0805 |
| Popis: | One prediction of the protease-antiprotease hypothesis of chronic obstructive pulmonary disease (COPD) pathogenesis is the appearance of elastin-derived degradation products in the plasmas of affected patients that are due to the breakdown of alveolar interstitial elastin by an excess of elastolytic activity in the lung. We previously demonstrated a significant elevation of plasma elastin-derived peptides (EDP) in subjects with COPD in comparison with asymptomatic smokers with normal spirometry or normal nonsmokers. To better determine the selectivity of the assay for EDP as a marker of COPD, we measured plasma EDP levels in different patient populations. These included subjects with COPD, subjects with diseases that may involve accelerated elastolysis (pneumonia, atherosclerotic vascular disease, and inflammatory arthritis), subjects with diseases hypothesized to involve pulmonary inflammation without elastolysis (asthma and acute tracheobronchitis), asymptomatic smokers with normal spirometry, and healthy, nonsmoking subjects. Mean plasma EDP levels in subjects with COPD were elevated above those in all other subjects (p less than 0.01). The prospective analyses of specificity and sensitivity of plasma EDP levels as markers of COPD gave values of 91 and 65%, respectively. Utilizing receiver operating characteristic curve analysis to assess the diagnostic and screening performance of plasma EDP as a test for COPD (perfect test equals an area under the curve of 1.0), the area under the curve was 0.87, which compares favorably with many widely used clinical tests. These data demonstrate that the assay for plasma EDP is a quantitative, easily measured, and highly specific marker for subjects with COPD. |
| Databáze: | OpenAIRE |
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