Sulpiride in tardive dyskinesia
| Autor: | B Sharf, M Schwartz, L Moguillansky, G Lanyi |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Dyskinesia Drug-Induced medicine.medical_specialty Tardive dyskinesia chemistry.chemical_compound Internal medicine Dopamine receptor D2 medicine Humans Single-Blind Method Benzamide Aged Aged 80 and over Neurologic Examination Dopamine antagonist Middle Aged medicine.disease Long-Term Care Abnormal involuntary movement Psychiatry and Mental health Endocrinology chemistry Dyskinesia Schizophrenia Female Surgery Neurology (clinical) Sulpiride medicine.symptom Psychology Antipsychotic Agents Research Article medicine.drug |
| Zdroj: | Journal of Neurology, Neurosurgery & Psychiatry. 53:800-802 |
| ISSN: | 0022-3050 |
| DOI: | 10.1136/jnnp.53.9.800 |
| Popis: | The abnormal involuntary movements in tardive dyskinesia can be reduced by the dopamine antagonist drugs, phenothiazines and butyrophenones, but most cause an increase in Parkinsonian signs. Sulpiride, a benzamide derivative, and selective antagonist of D2 receptors had a significantly beneficial effect on most of 15 patients (p less than 0.01). In 12 patients the improvement was marked. The reduction of abnormal movements was observed even with low doses, and it was not necessary to increase the dose of sulpiride above 600 mg daily. There were no significant side effects during the trial nor during an additional three months of treatment. |
| Databáze: | OpenAIRE |
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