Deregulated expression of the polycomb-group protein SUZ12 target genes characterizes mantle cell lymphoma
| Autor: | Esther María Sánchez Sánchez, Miguel A. Piris, Margarita Sánchez-Beato, Javier Suela, Lorena Di Lisio, Nerea Martinez, Javier Alves, Pierfrancesco Vargiu, Lorena Maestre, Daniel Martín-Pérez |
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| Rok vydání: | 2010 |
| Předmět: |
DNA Repair
DNA repair Cellular differentiation Apoptosis macromolecular substances Lymphoma Mantle-Cell Biology Pathology and Forensic Medicine Cell Line medicine SUZ12 Humans Nuclear protein Oligonucleotide Array Sequence Analysis Gene Expression Profiling EZH2 Polycomb Repressive Complex 2 Cancer Nuclear Proteins Cell Differentiation medicine.disease Neoplasm Proteins Gene expression profiling Gene Expression Regulation Neoplastic Cancer research Mantle cell lymphoma Carrier Proteins Transcription Factors Regular Articles |
| Zdroj: | The American journal of pathology. 177(2) |
| ISSN: | 1525-2191 |
| Popis: | Polycomb proteins are known to be of great importance in human cancer pathogenesis. SUZ12 is a component of the Polycomb PRC2 complex that, along with EZH2, is involved in embryonic stem cell differentiation. EZH2 plays an essential role in many cancer types, but an equivalent involvement of SUZ12 has not been as thoroughly demonstrated. Here we show that SUZ12 is anomalously expressed in human primary tumors, especially in mantle cell lymphoma (MCL), pulmonary carcinomas and melanoma, and is associated with gene locus amplification in some cases. Using MCL as a model, functional and genomic studies demonstrate that SUZ12 loss compromises cell viability, increases apoptosis, and targets genes involved in central oncogenic pathways associated with MCL pathogenesis. Our results support the hypothesis that the abnormal expression of SUZ12 accounts for some of the unexplained features of MCL, such as abnormal DNA repair and increased resistance to apoptosis. |
| Databáze: | OpenAIRE |
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