Studies on host specificity in Paragonimus westermani: Ultrastructural study of inflammatory reactions to the parasite in rat muscles
| Autor: | Takemi Oguma, Fusanori Hamajima, T. Fujino, Koichi Fukuda |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Paragonimus westermani
Pathology medicine.medical_specialty Paragonimiasis Brachyura Paragonimus Inflammation Rats Sprague-Dawley Rodent Diseases Immune system Species Specificity Antigen parasitic diseases medicine Animals Eosinophil degranulation biology Muscles fungi Degranulation Eosinophil biology.organism_classification Rats Infectious Diseases medicine.anatomical_structure biology.protein Parasitology Antibody medicine.symptom |
| Zdroj: | International Journal for Parasitology. 23:757-763 |
| ISSN: | 0020-7519 |
| Popis: | Inflammatory reactions to the lung fluke, Paragonimus westermani, in an abnormal host, the rat, were studied by electron microscopy. Inflammatory cells accumulated around the worms in rat muscles, but the reaction varied significantly in intensity as well as distribution of inflammatory cells from worm to worm in the same and different hosts. In an accumulation of inflammatory infiltrates around the worm, eosinophils were more commonly seen, and neutrophils and macrophages were fewer in number. Mast cells appeared rarely. Where inflammatory cells touched to the worms, the tegument of the worms was covered with moderately electron-dense flocculent material which included dense granules. This material, which probably consisted of immune complexes of host antibody and antigen secreted from tegumental granules, seemed to block the inflammatory cells from adhering to the worm surfaces. Inflammatory cells made direct contact with worm surfaces where flocculent material was absent. Dense secretory material was discharged from some eosinophils as a result of degranulation. |
| Databáze: | OpenAIRE |
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