Varicella‐Zoster Virus–Specific Cellular Immunity in Subjects Given Acyclovir after Household Chickenpox Exposure
| Autor: | Hiroyuki Kojima, Shoki Yano, Hidetsugu Furukawa, Takuji Kumagai, Shunzo Chiba, Chiharu Igarashi, Makoto Kamada, Akiko Saito, Toyo Okui, Kenji Yuri |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Herpesvirus 3 Human Cellular immunity Time Factors viruses Immunization Secondary Acyclovir chemical and pharmacologic phenomena Antibodies Viral medicine.disease_cause Antiviral Agents Herpesviridae Virus Chickenpox Vaccine Chickenpox medicine Humans Immunology and Allergy Family Aciclovir Immunity Cellular integumentary system business.industry Varicella zoster virus Infant virus diseases biochemical phenomena metabolism and nutrition medicine.disease Virology Community-Acquired Infections Infectious Diseases Immunization Child Preschool Antibody Formation Immunology Female business medicine.drug |
| Zdroj: | The Journal of Infectious Diseases. 180:834-837 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/314950 |
| Popis: | The time course of primary cell-mediated immune responses to varicella-zoster virus (VZV) among persons receiving acyclovir prophylaxis after exposure to chickenpox has not been well defined. Fifteen children who had household exposure to varicella received prophylactic acyclovir (40 mg/kg/day for 7-14 days after exposure) and were studied for development of both antibody and cell-mediated immunity (CMI) to VZV. Twelve developed antibodies and/or CMI; 10 had no symptoms and 2 manifested mild varicella. Two were already immune to varicella and had booster immune responses. One was not infected and subsequently developed full-blown varicella. Although acyclovir given after exposure to VZV is highly effective and does not appear to attenuate the immune response, it remains necessary to confirm whether, in the absence of clinical varicella, persons acquire specific immunity. |
| Databáze: | OpenAIRE |
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