Influence of genetic and non-genetic factors on acenocoumarol maintenance dose requirement in a Tunisian population
| Autor: | Marwa Ajmi, Ali Bouslama, Fatma Ben Fredj Ismail, Nabila Ben Rejeb, Haithem Hamdouni, Dorra Amor, Slim Achour, Chedia Laouani Kechrid, Essia Boughzela, Asma Omezzine |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Tunisia Adolescent Genotype CYP4F2 Black People Hemorrhage 030204 cardiovascular system & hematology Polymorphism Single Nucleotide Gastroenterology Young Adult 03 medical and health sciences 0302 clinical medicine Vitamin K Epoxide Reductases Internal medicine Atrial Fibrillation medicine Humans Pharmacology (medical) Cytochrome P450 Family 4 International Normalized Ratio CYP2C9 Aged Cytochrome P-450 CYP2C9 Aged 80 and over Venous Thrombosis Pharmacology Acenocoumarol business.industry Maintenance dose Calcium-Binding Proteins Haplotype Anticoagulants General Medicine Middle Aged 030220 oncology & carcinogenesis Cohort Female VKORC1 business Algorithms Pharmacogenetics medicine.drug |
| Zdroj: | European Journal of Clinical Pharmacology. 74:711-722 |
| ISSN: | 1432-1041 0031-6970 |
| DOI: | 10.1007/s00228-018-2423-7 |
| Popis: | We aimed to study potential variables involved in interindividual variability to acenocoumarol (AC) response in order to establish a pharmacogenetic algorithm (PA) that includes clinical and genetic factors to predict adequate AC dose to stabilize anticoagulation in a cohort of Tunisian patients. Genotyping of the CYP2C9, VKORC1, CYP4F2, and CALU polymorphisms was conducted on 246 patients using PCR-RFLP technique. AC normalized maintenance dose (NMD): ((mean maintenance dose/international normalized ratio (INR)) equilibrium) was calculated. The statistical study was carried out with SPSS V20. A significant correlation was found between age, BMI, and daily AC dose (r = − 0.397; p |
| Databáze: | OpenAIRE |
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