Analysis of tricyclic antidepressant drugs by gas chromatography using nitrogen-selective detection with packed and capillary columns
| Autor: | M. Sanjuan, V. Rovei, P.D. Hrdina |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Packed bed
Chromatography Gas Chromatography Capillary action Extraction (chemistry) chemistry.chemical_element Tricyclic antidepressant drugs General Chemistry Antidepressive Agents Tricyclic Nitrogen Hexane Structure-Activity Relationship chemistry.chemical_compound chemistry Humans Gas chromatography Derivatization |
| Zdroj: | Journal of Chromatography B: Biomedical Sciences and Applications. 182:349-357 |
| ISSN: | 0378-4347 |
| DOI: | 10.1016/s0378-4347(00)81484-x |
| Popis: | A gas chromatographic method using either a conventional packed column (3% SP-2250) or a capillary column (SE-30) for the measurement of therapeutic plasma concentrations of tricyclic antidepressant drugs and their demethylated metabolites is described. The technique is based on a simple hexane extraction of drugs from alkalinized plasma followed by derivatization with heptafluorobutyric anhydride for the measurement of demethylated compounds. Subsequently, parent drugs and derivatives are chromatographed and detected using a nitrogen-selective detector. A comparison of the results using both types of chromatographic systems is discussed. |
| Databáze: | OpenAIRE |
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