Role of glia-derived cholesterol in synaptogenesis: new revelations in the synapse–glia affair
| Autor: | Frank W. Pfrieger, Daniela H. Mauch, Christian Göritz, Karl Nägler |
|---|---|
| Přispěvatelé: | Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2002 |
| Předmět: |
Apolipoprotein E
Central nervous system Synaptogenesis Cell Communication Biology Retinal ganglion Synapse 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Physiology (medical) medicine Animals Cholesterol metabolism 030304 developmental biology Neurons 0303 health sciences Cholesterol General Neuroscience medicine.anatomical_structure chemistry Synapses Neuroglia lipids (amino acids peptides and proteins) Neuroscience [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology 030217 neurology & neurosurgery |
| Zdroj: | Journal of Physiology-Paris Journal of Physiology-Paris, Elsevier, 2002, 96 (3-4), pp.257-263. ⟨10.1016/s0928-4257(02)00014-1⟩ |
| ISSN: | 0928-4257 |
| DOI: | 10.1016/s0928-4257(02)00014-1 |
| Popis: | Brain development and function relies on the exchange of signals between neurons and glial cells. Here we review a series of recent studies on cultures of purified retinal ganglion cells (RGCs) that point to a new role of glial cells in the formation and plasticity of synaptic connections. The results suggest that neurons must import glia-derived cholesterol via lipoproteins to form numerous and efficient synaptic connections. This finding may explain why throughout the central nervous system (CNS) the main phase of synaptogenesis starts synchronously after glia differentiation and why astrocytes produce apolipoprotein E (apoE) and cholesterol-containing lipoproteins. Experimental tests of these hypotheses may further our understanding of the cholesterol metabolism in the brain and may help to explain neurologic symptoms resulting from defective cholesterol and lipoprotein metabolism. |
| Databáze: | OpenAIRE |
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