Repeatability and reproducibility of Cobra HD fundus camera meibography in young adults with and without symptoms of dry eye

Autor: Reut Ifrah, Lluisa Quevedo, Liat Gantz
Přispěvatelé: Universitat Politècnica de Catalunya. Doctorat en Enginyeria Òptica, Universitat Politècnica de Catalunya. Departament d'Òptica i Optometria, Universitat Politècnica de Catalunya. VOS - Visió, Optometria i Salut
Rok vydání: 2022
Předmět:
Zdroj: Ophthalmicphysiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)REFERENCES.
ISSN: 1475-1313
Popis: Purpose: The inter-session repeatability (ISR), inter-examiner reproducibility (IER) and within-subject variability (WSV) of the Cobra HD fundus camera meibographer were examined in participants with and without dry eye symptoms.Methods: Symptoms were determined based on Ocular Surface Disease Index scores (=13 being considered symptomatic), and subgroups were compared using the Mann– Whitney U- test. Images of meibomian glands (MGs) from the upper and lower right eyelids were captured by two examiners on the same day (S1) to determine IER. One examiner repeated the measurements on a second day (S2) to obtain the ISR. ISR, IER and WSV were calculated using Friedman, correlation tests and Bland and Altman analyses with mean differences (md) and 95% confidence intervals (CIs), within-subject standard deviations (Sw) and intra-class correlation coefficients (ICC).Results: The ISR experiment included 72 participants (mean age: 23 ± 5 years, range: 19–43, 36 symptomatic). Mean MG loss of the upper (S1: 13.5 ± 9.5%, S2: 12.8 ± 8.5%) and lower eyelids (S1: 7.5 ± 6.9%, S2: 7.3 ± 6.3%) was not significantly different between sessions for all participants, symptomatic and asymptomatic subgroups for both eyelids. The ISR Sw for the upper and lower eyelids was 1.3% and 1.0%; md was 0.7 ± 3.5% (CI:-6.25% to 7.62%) and 0.1 ± 2.1% (CI: -3.94% to 4.17%), respectively. The IER experiment included 74 participants (mean age: 23 ± 5 years, range: 19–43, 37 symptomatic). Mean MG loss of the upper (Examiner 1: 12.7 ± 8.2%, Examiner 2: 13.1 ± 8.0%) and lower eyelids (Examiner 1: 7.0 ± 6.2%, Examiner 2: 7.4 ± 6.2%) was not significantly different between examiners for all participants, symptomatic and asymptomatic subgroups for both eyelids. The IER ICC values were >0.86 for all conditions, Sw was 1.3% and 1.2%, with a md of -0.4 ± 3.2% (CI: -6.65% to 5.90%) and -0.4 ± 2.9% (CI: -6.15% to 5.31%), respectively. The WSV Sw values were 0.89 for both eyelids, examiners and experimental sessions.Conclusions: The Cobra HD fundus camera demonstrates good repeatability, reproducibility and low WSV, and is a reliable clinical instrument for meibography.
Databáze: OpenAIRE
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