| Autor: |
Aniki Rothova, S Boukhrissi, Marco W.J. Schreurs, D.P.C. Vergouwen, J.C. Ten Berge |
| Přispěvatelé: |
Ophthalmology, Immunology |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Ocular Immunology and Inflammation. Taylor & Francis Ltd |
| ISSN: |
0927-3948 |
| DOI: |
10.1080/09273948.2021.1966050 |
| Popis: |
PurposeScleritis is a potentially blinding disorder, with highly unpredictable course and outcome. We analyzed the prevalence and clinical relevance of autoantibodies and inflammatory parameters in non-infectious scleritis.MethodsRetrospective analysis of laboratory findings in all consecutive patients at the department of Ophthalmology of the Erasmus MC with non-infectious scleritis.ResultsWe included 81 patients with non-infectious scleritis. A systemic autoimmune disease was present in 46%. Positive anti-nuclear antibodies were found in 30%, anti-neutrophil cytoplasmic antibodies were positive in 19%, and the presence of rheumatoid factor was shown in 17%. The aforementioned autoantibodies, as well as inflammatory parameters, failed to show prognostic clinical value. In contrast, anti-citrullinated peptide antibodies (ACPA), found in 9% of scleritis patients, were significantly associated with the development of scleral necrosis (P = .01).ConclusionsThe presence of ACPA in patients with non-infectious scleritis was associated with the development of scleral necrosis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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