Study of the impact of long-duration space missions at the International Space Station on the astronaut microbiome

Autor:	Duane L. Pierson, Kelvin J. Moncera, Manolito Torralba, Yun Zhang, Cherie Oubre, Hernan Lorenzi, C. Mark Ott, Brian Crucian, Alexander A. Voorhies, Satish K. Mehta, Alan H. Feiveson, Eduardo E. Zurek
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	DNA Bacterial 0301 basic medicine Time Factors Skin rashes media_common.quotation_subject Cytokine profile health care facilities manpower and services Science Crew Outer space Microbiology Article Space exploration 03 medical and health sciences 0302 clinical medicine Environmental health International Space Station Humans Medicine Longitudinal Studies Microbiome Saliva Short duration media_common Multidisciplinary Bacteria business.industry Microbiota Space Flight Computational biology and bioinformatics 030104 developmental biology Astronauts Cytokines business 030217 neurology & neurosurgery Environmental Monitoring
Zdroj:	Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019) Scientific Reports
ISSN:	2045-2322
Popis:	Over the course of a mission to the International Space Station (ISS) crew members are exposed to a number of stressors that can potentially alter the composition of their microbiomes and may have a negative impact on astronauts’ health. Here we investigated the impact of long-term space exploration on the microbiome of nine astronauts that spent six to twelve months in the ISS. We present evidence showing that the microbial communities of the gastrointestinal tract, skin, nose and tongue change during the space mission. The composition of the intestinal microbiota became more similar across astronauts in space, mostly due to a drop in the abundance of a few bacterial taxa, some of which were also correlated with changes in the cytokine profile of crewmembers. Alterations in the skin microbiome that might contribute to the high frequency of skin rashes/hypersensitivity episodes experienced by astronauts in space were also observed. The results from this study demonstrate that the composition of the astronauts’ microbiome is altered during space travel. The impact of those changes on crew health warrants further investigation before humans embark on long-duration voyages into outer space.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3ea7615b655685e9fb40cf85fb76fdd https://doaj.org/article/a5cf7868343a469e881872fed67500f3 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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