PGK1 a Potential Marker for Peritoneal Dissemination in Gastric Cancer
| Autor: | Christian Stirnkorb, Falko Fend, Hinnak Northoff, Derek Zieker, Bettina Knapp, Björn L.D.M. Brücher, Frank Traub, Alfred Königsrainer, Ingmar Königsrainer, Susan Kupka, Christian Schillinger, Kay Nieselt |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Physiology Abdominal cavity CXCR4 Stomach Neoplasms Internal medicine Biomarkers Tumor medicine Humans In patient RNA Messenger Peritoneal Neoplasms Aged Oligonucleotide Array Sequence Analysis business.industry Gene Expression Profiling Cancer Middle Aged medicine.disease Peritoneal carcinomatosis Gene Expression Regulation Neoplastic Phosphoglycerate Kinase medicine.anatomical_structure Cancer cell Female business |
| Zdroj: | Cellular Physiology and Biochemistry. 21:429-436 |
| ISSN: | 1421-9778 1015-8987 |
| Popis: | Peritoneal carcinomatosis, which is caused by the dissemination of cancer cells into the abdominal cavity is a frequent finding in patients with primary gastric cancer, and it is associated with a poor prognosis. The mechanisms that mediate peritoneal carcinomatosis in diffuse primary gastric tumours require definition.We therefore compared the gene expression profile in diffuse primary gastric cancer patients with and without peritoneal carcinomatosis (n=13). Human specimens from consecutive gastric cancer patients with and without peritoneal carcinomatosis were investigated using oligonucleotide microarrays. Differentially expressed genes of interest were further evaluated using quantitative real-time polymerase chain reaction (qRT-PCR).The results reveal a significant overexpression of phosphoglycerate kinase 1 (PGK1), the chemokine CXCR4 and its ligand CXCL12 in specimens from diffuse gastric cancer patients with peritoneal carcinomatosis. Overexpression of PGK1 is known to increase the expression of CXCR4. CXCR4 on its part can increase CXCL12 expression. Elevated levels of CXCR4 and CXCL12 are associated with an increase in the metastatic rate and play an important role in the metastatic homing of malignant cells.The overexpression of PGK1 and its signalling targets may be a expression-pathway in diffuse primary gastric carcinomas promoting peritoneal dissemination and may function as prognostic markers and/or be potential therapeutic targets to prevent the migration of gastric carcinoma cells into the peritoneum. |
| Databáze: | OpenAIRE |
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