Monocyte lymphocyte ratio As a predictor of Diabetic Kidney Injury in type 2 Diabetes mellitus; The MADKID Study
| Autor: | Hikmet Tekce, Mehmet Zahid Kocak, Ozge Kurtkulagi, Burcin M. Atak, Betül Alaca, Satilmis Bilgin, Gulali Aktas, Tuba Taslamacioglu Duman |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Endocrinology Diabetes and Metabolism Lymphocyte chemical and pharmacologic phenomena Inflammation Logistic regression Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus Internal Medicine medicine Predictive marker business.industry Monocyte Type 2 Diabetes Mellitus medicine.disease 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Microalbuminuria medicine.symptom business Research Article |
| Zdroj: | J Diabetes Metab Disord |
| ISSN: | 2251-6581 |
| DOI: | 10.1007/s40200-020-00595-0 |
| Popis: | AIMS: Inflammation is a cardinal pathogenetic mechanism in diabetic kidney injury (DKI). The detection of microalbuminuria (MA) is very important in preventing end-stage renal failure in diabetic subjects. A combination of high monocyte and low lymphocyte counts are used as a marker of inflammation. Monocyte to lymphocyte ratio (MLR) is considered as a marker in inflammatory diseases. We aimed to evaluate the MLR levels in diabetic subjects as a predictive marker in detecting MA. METHODS: A total of 212 patients with type 2 diabetes mellitus (T2DM) were included in the study. Patients with T2DM were divided into two groups as MA and normoalbuminuria (NA). MLR of the groups were compared. RESULTS: There were 72 patients in MA and 140 patients in NA group. MLR of the MA and NA groups were 0.247 (0.131–0.540) and 0.211 (0.052–0.390), respectively (p |
| Databáze: | OpenAIRE |
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