Different radiation susceptibility among five strains of mice detected by a skin reaction
| Autor: | Yoshinobu Harada, Miyako Goto, Miyuki Wakabayashi, Mayumi Iwakawa, Ryonfa Lee, Chisa Ohira, Yoshifumi Matsui, Toshie Ohta, Takashi Imai, Shuhei Noda |
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| Rok vydání: | 2003 |
| Předmět: |
Pathology
medicine.medical_specialty Radiation Strain (chemistry) Health Toxicology and Mutagenesis medicine.medical_treatment Histology Dose-Response Relationship Radiation Mice Inbred Strains Biology Radiation Tolerance Radiation therapy Skin reaction Dose–response relationship Mice Species Specificity Apoptosis Gamma Rays medicine Animals Radiology Nuclear Medicine and imaging Female Irradiation Radiosensitivity Skin |
| Zdroj: | Journal of radiation research. 44(1) |
| ISSN: | 0449-3060 |
| Popis: | Published reports about skin reactions to radiotherapy, especially among breast-cancer patients, suggest that there are interindividual differences in the normal tissue response, and genetic factors are thought to be involved in this variation. An analysis of murine strain differences may reveal the mechanism of genetic factors in the extent of normal tissue damage from irradiation for several endpoints. The variation in the radiation susceptibility was observed when the skin of mice from strains A/J, C3H/HeMs, C57BL/6J, C.B.17/Icr-scid and C3H-scid was irradiated with a single dose ranging from 10 to 60 Gy, using Cs-137 gamma rays. The active skin reaction of A/J mice lasted for months. C3H/HeMs mice showed dose-dependent skin damage, and consequently recovered to a state of mild damage within 40 days after local irradiation. The time course of the response in C57BL/6J mice was shorter than in A/J mice. The 2 strains of scid mice exhibited severe damage after irradiation at any dose from 20 to 50 Gy, and did not show any dose dependency. The variation between murine strains in macroscopic and histopathological changes in skin during the progression and resolution of damage caused by irradiation suggests an inter-strain variation in the expression of genes involved in injury, apoptosis, repair, and remodeling. |
| Databáze: | OpenAIRE |
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