Synthesis and Cytotoxicity Evaluation of a Series of 3-Alkenyl-2-Hydroxy1,4-Naphthoquinones Obtained by an Efficient Knoevenagel Condensation
| Autor: | Celso A. Camara, Julia F. Campos, Gardenia C.G. Militão, Tania M. S. Silva, Cibelle C. David, Teresinha Gonçalves da Silva, Antônio Cláudio da Silva Lins |
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| Rok vydání: | 2018 |
| Předmět: |
Knoevenagel condensation
Phenylacetaldehyde 020209 energy Tumor cells 02 engineering and technology General Chemistry Catalysis Lawsone lawsone chemistry.chemical_compound Acetic acid chemistry 3-alkenyl-2-hydroxy-1 4-naphthoquinones 0202 electrical engineering electronic engineering information engineering Organic chemistry 1 4-naphthoquinones Cytotoxicity Isobutyraldehyde cytotoxic evaluation |
| Zdroj: | Journal of the Brazilian Chemical Society, Volume: 30, Issue: 1, Pages: 18-8, Published: JAN 2019 Journal of the Brazilian Chemical Society v.30 n.1 2019 Journal of the Brazilian Chemical Society Sociedade Brasileira de Química (SBQ) instacron:SBQ |
| ISSN: | 1678-4790 0103-5053 |
| DOI: | 10.21577/0103-5053.20180146 |
| Popis: | A modified and efficient Knoevenagel condensation procedure was developed to synthesize the title compounds using β-alanine and acetic acid as catalysts, showing good to excellent yields. We used lawsone with suitable aliphatic aldehydes including isobutyraldehyde, 3-methyl-butyraldehyde, 2-ethylbutyraldehyde, phenylacetaldehyde, 2-phenyl-propionaldehyde, among others. These compounds were submitted to cytotoxic screening against three tumor cell lines presenting good to excellent cytotoxic profiles. |
| Databáze: | OpenAIRE |
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