Interaction of Leptospira with the Innate Immune System
| Autor: | Catherine Werts |
|---|---|
| Přispěvatelé: | Biologie et Génétique de la Paroi bactérienne - Biology and Genetics of Bacterial Cell Wall (BGPB), Institut Pasteur [Paris], Institut Pasteur [Paris] (IP) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
animal diseases Antimicrobial peptides MESH: Complement System Proteins Biology medicine.disease_cause MESH: Leptospira [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity Microbiology MESH: Receptors Pattern Recognition 03 medical and health sciences Immune system Immunity medicine Macrophage Innate immune system MESH: Humans MESH: Immune System [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health Pattern recognition receptor Pathogenic bacteria MESH: Leptospirosis [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology Complement system 030104 developmental biology MESH: Immunity Innate |
| Zdroj: | Spirochete Biology: The Post Genomic Era, ed. by Ben Adler Spirochete Biology: The Post Genomic Era, ed. by Ben Adler, 415, pp.163-187, 2017, Current Topics in Microbiology and Immunology, ⟨10.1007/82_2017_46⟩ Current Topics in Microbiology and Immunology ISBN: 9783319896373 |
| DOI: | 10.1007/82_2017_46⟩ |
| Popis: | International audience; Innate immunity encompasses immediate host responses that detect and respond to microbes. Besides recognition by the complement system (see the chapter by A. Barbosa, this volume), innate immunity concerns cellular responses. These are triggered through recognition of conserved microbial components (called MAMPs) by pattern recognition receptors (PRRs), leading, through secretion of cytokines, antimicrobial peptides, and immune mediators, to cellular recruitment and phagocytosis. Leptospira spp. are successful zoonotic pathogenic bacteria that obviously overcome the immune system of their hosts. The first part of this chapter summarizes what is known about leptospires recognition and interaction with phagocytes and other innate immune cells, and the second part describes specific interactions of leptospiral MAMPs with PRRs from the TLR and NLR families. On the one hand, pathogenic leptospires appear to escape macrophage and neutrophil phagocytosis. On the other hand, studies about PRR sensing of leptospires remain very limited, but suggest that pathogenic leptospires escape some of the PRRs in a host-specific manner, due to peculiar cell wall specificities or post-translational modifications that may impair their recognition. Further studies are necessary to clarify the mechanisms and consequences of leptospiral escape on phagocytic functions and hopefully give clues to potential therapeutic strategies aimed at restoring the defective activation of PRRs by pathogenic Leptospira spp. |
| Databáze: | OpenAIRE |
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