Risk factors associated with portal vein thrombosis in liver cirrhosis: A case-control study
| Autor: | Vladimir Ivashkin, K A Ulyanova, S I Rogacheva, A S Dekhanov, M Yu Nadinskaia, D A Strelkova, Kh B Kodzoeva, A S Volkova |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Liver Cirrhosis Male History medicine.medical_specialty Cirrhosis case-control study Endocrinology Diabetes and Metabolism lcsh:Medicine Portal hypertensive gastropathy Gastroenterology 03 medical and health sciences 0302 clinical medicine Spontaneous bacterial peritonitis Risk Factors Internal medicine Ascites Hypertension Portal medicine Prevalence Humans portal vein thrombosis child-pugh class Venous Thrombosis business.industry Portal Vein local factors lcsh:R Liver Neoplasms portal hypertension hepatocellular carcinoma General Medicine Middle Aged logistic regression model medicine.disease Portal vein thrombosis 030220 oncology & carcinogenesis Hepatocellular carcinoma Case-Control Studies Portal hypertension 030211 gastroenterology & hepatology Female medicine.symptom Family Practice business Complication Tomography X-Ray Computed |
| Zdroj: | Терапевтический архив, Vol 91, Iss 2, Pp 73-81 (2019) |
| ISSN: | 0040-3660 |
| Popis: | Background. Portal vein thrombosis (PVT) in patients with liver cirrhosis is a common complication associated with adverse outcomes. The aim of the study was to build a predictive model for PVT in cirrhotic patients. Materials and methods. A single centre case-control study was carried out. From the database of 1512 cirrhotic patients 94 with newly diagnosed PVT based on contrast-enhanced computed tomography were referred to the Case group. Malignant PVT was an exclusion criterion. Patients without PVT were stratified and matched according to sex, age and etiology of cirrhosis; case-control ratio was 1 : 3-4. The prevalence of PVT in the database, clinical, laboratory, instrumental parameters of the groups were evaluated. Logistic regression model was used to estimate association between variables and PVT. Results. The overall prevalence of PVT was 6.2% with the highest rates among the patients with HBV infection 16.7%, nonalcoholic steatohepatitis 15.6%, alcohol abuse in combination with HCV infection 11.7%. The best predictive model included variables: Child-Pugh classes B-C (coefficient of regression b=1.853, р=0.001), ascites (b=0.460, р=0.003), hepatocellular carcinoma without vascular invasion (b=2.126, р=0.0001), endoscopic band ligation (b=0.774, р=0.003), transabdominal esophagogastric devascularization procedure (b=2.734, р=0.001), portal hypertensive gastropathy (b=0.793, р=0.017), portal vein diameter (b=0.203, р=0.004), and local factors ulcerative colitis flare, Clostridium difficile enterocolitis, spontaneous bacterial peritonitis, colorectal cancer, splenectomy, cholecystectomy (b=2.075, р=0.017). The model had accuracy 85.8% (95% CI 81.7-89.4%), sensitivity 55.1% (95% CI 43.4-66.4%), specificity 95% (95% CI 91.6-97.3%), and AUC 0.871 (95% CI 0.826-0.916). Conclusion. Child-Pugh classes B-C, severe portal hypertension, hepatocellular carcinoma without vascular invasion, and local factors were estimated as risk factors of PVT in cirrhotic patients. |
| Databáze: | OpenAIRE |
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