Socio-economic status and outcomes for patients with age-related macular degeneration
| Autor: | Pradnya More, Hussein Almuhtaseb, Dianna Smith, Simon Fraser, Andrew J. Lotery |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A medicine.medical_specialty Visual acuity Recombinant Fusion Proteins Visual Acuity Disease Logistic regression Article 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Socioeconomic status Aged Retrospective Studies Aflibercept Aged 80 and over Univariate analysis business.industry Retrospective cohort study Middle Aged Patient Acceptance of Health Care Macular degeneration medicine.disease Ophthalmology Receptors Vascular Endothelial Growth Factor Treatment Outcome Socioeconomic Factors Intravitreal Injections Wet Macular Degeneration 030221 ophthalmology & optometry Female medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Eye (Lond) |
| ISSN: | 1476-5454 0950-222X |
| DOI: | 10.1038/s41433-019-0393-3 |
| Popis: | Objectives: to explore disparities in severity of baseline disease, treatment completion and treatment outcomes among patients with wet age-related macular degeneration (AMD) receiving anti-vascular endothelial growth factor therapy by socio-economic status (SES) and distance from home to hospital. Study design: retrospective cohort study.Methods: data from clinic records of 756 wet AMD patients receiving treatment for wet AMD with aflibercept between May 2013 and Jan 2017 were obtained. Area SES (using Index of Multiple Deprivation (IMD) 2015) and distance from hospital (dichotimised >=10 vs Results: living in the most deprived compared with less deprived areas was associated with a significantly higher risk of presenting with severe reduction in VA (OR=3.59; 95% CI=1.39-9.27; P=.01). This association was maintained after adjustment for age, gender and distance from hospital.On univariate analysis, delayed treatment completion was more likely in those living in most deprived areas (OR=2.80; 95% CI=1.21-6.47; P=.04), though this association was attenuated after adjustment for age, gender and distance from hospital.No association was observed between SES and treatment outcomes or between distance from hospital and baseline VA, treatment completion or treatment outcome.Conclusion: this study found poorer baseline VA among people with wet AMD from more deprived areas. This work suggests a need for earlier identification of AMD among more deprived populations. |
| Databáze: | OpenAIRE |
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