Levels of Lipoprotein (a) in patients with coronary artery disease with and without inflammatory rheumatic disease: A cross-sectional study
| Autor: | Ingvild Oma, Sverre Holm, Bente Halvorsen, Thor Ueland, Pål Aukrust, Hans Rydningen, Kjell Saatvedt, Frank Brosstad, Ivar Risnes, Ivana Hollan, Sven M. Almdahl, Knut Mikkelsen, Tor-Arne Hagve |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Cross-sectional study rheumatology Disease Coronary Artery Disease 030204 cardiovascular system & hematology Cardiovascular Medicine Coronary artery disease Cohort Studies 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Rheumatic Diseases parasitic diseases medicine Humans cardiovascular diseases Risk factor coronary heart disease Aged 030203 arthritis & rheumatology Inflammation biology business.industry Research C-reactive protein General Medicine Lipoprotein(a) Middle Aged medicine.disease Rheumatology Cross-Sectional Studies atherosclerosis biology.protein Female business Cohort study |
| Zdroj: | BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | ObjectivesPatients with various inflammatory rheumatic diseases (IRDs) have increased risk of atherothrombotic disease. Lipoprotein (a) (Lp(a)) is a risk factor for atherosclerosis but its role in IRD with accompanying coronary artery disease (CAD) is still unclear. We aimed to examine if serum Lp(a) levels differed between CAD patients with and without accompanying IRD.DesignA cross-sectional observational, patient-based cohort study.SettingReferred centre for coronary artery bypass grafting in the South Eastern part of Norway.Participants67 CAD patients with IRD (CAD/IRD) and 52 CAD patients without IRD (CAD/non-IRD). All patients were Caucasians, aged >18 years, without any clinically significant infection or malignancy.MethodsLp(a) levels in serum were analysed by particle enhanced immunoturbidimetric assay, and Lp(a) levels were related to clinical and biochemical characteristics of the patient population.ResultsWe found no differences in serum levels of Lp(a) between CAD patients with and without IRD. In general, we found that Lp(a) correlated poorly with clinical and biochemical parameters including C reactive protein with the same pattern in the CAD/non-IRD and CAD/IRD groups.ConclusionsOur data do not support a link between inflammation and Lp(a) levels in CAD and in general Lp(a) levels were not correlated with other risk factors for cardiovascular disease. |
| Databáze: | OpenAIRE |
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