Detection of Glaucomatous Progression by Spectral-Domain Optical Coherence Tomography
| Autor: | Yong Ho Sohn, Kyung Rim Sung, Hwang Ki Kim, Jung Hwa Na, Jong Rak Lee, Kyoung Sub Lee, Seunghee Baek |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Retinal Ganglion Cells medicine.medical_specialty genetic structures Optic Disk Gonioscopy Visual Acuity Nerve fiber layer Glaucoma Spectral domain chemistry.chemical_compound Nerve Fibers Optical coherence tomography Ophthalmology Optic Nerve Diseases Humans Medicine Intraocular Pressure Retrospective Studies medicine.diagnostic_test business.industry Retinal Middle Aged medicine.disease eye diseases Visual field medicine.anatomical_structure ROC Curve chemistry Disease Progression Optic nerve Visual Field Tests Optometry Female sense organs Visual Fields business Tomography Optical Coherence Follow-Up Studies Optic disc |
| Zdroj: | Ophthalmology. 120:1388-1395 |
| ISSN: | 0161-6420 |
| DOI: | 10.1016/j.ophtha.2012.12.014 |
| Popis: | To compare the rate of change of circumpapillary retinal nerve fiber layer (cRNFL) thickness, macular volume and thickness, and optic nerve head (ONH) parameters assessed using spectral-domain optical coherence tomography (SD-OCT) between eyes with progressing and nonprogressing glaucoma.Longitudinal, observational study.Two hundred seventy-nine eyes from 162 glaucoma patients followed for an average of 2.2 years.Eyes were classified as progressors and nonprogressors according to assessment of optic disc and RNFL photographs and visual field progression analysis. Linear mixed effects models were used to evaluate the overall rate of change of cRNFL thickness, macular volume and thickness, and ONH parameters after adjustment for age, spherical equivalent, signal strength, and baseline SD-OCT measurements.The rate of change of cRNFL thickness, macular volume, and thickness and ONH parameters.Sixty-three eyes (22.6%) from 52 subjects were identified as progressors. Average, inferior quadrant, and 6- and 7-o'clock sector cRNFL thickness decreased faster in progressors than in nonprogressors (-1.26 vs -0.94, -2.47 vs -1.75, -3.60 vs -2.52, and -2.77 vs -1.51 μm/year, respectively; all P0.05). The ONH rim area decreased faster, and average and vertical cup-to-disc ratio increased faster in progressors than in nonprogressors (-0.016 vs -0.006 mm(2)/year, and 0.004 vs 0.002 and 0.006 vs 0.004 per year, respectively; all P0.05). Macular cube volume and the thickness of temporal outer and inferior inner macular sectors decreased faster in progressors than in nonprogressors (-0.068 vs -0.048 mm(3)/year, and -2.27 vs -1.67 and -2.51 vs -1.73 μm/year, respectively; all P0.05).Serial measurement of parameters in all 3 areas (cRNFL, macula, and ONH) by SD-OCT may permit identification of progression in glaucomatous eyes.The authors have no proprietary or commercial interest in any of the materials discussed in this article. |
| Databáze: | OpenAIRE |
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