Antioxidant Enzymes and Lipid Peroxidation in Different Stages of Breast Cancer
Autor: | Suchet D. Khanzode, Shruti S. Khanzode, M.G. Muddeshwar, Ganesh N. Dakhale |
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Rok vydání: | 2004 |
Předmět: |
medicine.medical_specialty
Antioxidant medicine.medical_treatment Breast Neoplasms Ascorbic Acid medicine.disease_cause Biochemistry Antioxidants Superoxide dismutase Lipid peroxidation chemistry.chemical_compound Breast cancer Reference Values Malondialdehyde Internal medicine medicine Humans skin and connective tissue diseases Neoplasm Staging biology Superoxide Dismutase Chemistry General Medicine Ascorbic acid medicine.disease Enzymes Endocrinology Case-Control Studies Immunology biology.protein Female Lipid Peroxidation Carcinogenesis Oxidative stress |
Zdroj: | Free Radical Research. 38:81-85 |
ISSN: | 1029-2470 1071-5762 |
Popis: | Oxidative stress resulting from an imbalance between pro-oxidants and anti-oxidants seems to play an important role in human breast carcinogenesis. There are conflicting reports regarding the tissue levels of malondialdehyde (MDA), ascorbic acid and superoxide dismutase (SOD) in breast cancer patients whereas few blood values have been reported. The present study was carried out to observe the changes in serum MDA, serum SOD and plasma ascorbic acid with the stage-wise progression of the disease. Serum MDA and serum SOD levels were found to be increased gradually from Stage I to Stage IV as compared to control group (p < 0.001). The maximum rise was in Stage IV patients. In contrast, mean plasma ascorbic acid levels were low in all stages compared to control group (p < 0.001). The decrease was more pronounced in Stage III and Stage IV. The study would be of immense help for establishing blood based biochemical marker in breast cancer patients. |
Databáze: | OpenAIRE |
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