KLF8 is associated with poor prognosis and regulates glycolysis by targeting GLUT4 in gastric cancer
| Autor: | Anwei Mao, Yanxia Liu, Gaofeng Pan, Aiyu Miao, Junbin Ding, Xiang Zhou |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Kruppel-Like Transcription Factors medicine.disease_cause Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Stomach Neoplasms Cell Line Tumor Gene expression Biomarkers Tumor medicine Humans Gene silencing Glucose Transporter Type 4 business.industry gastric cancer Cancer KLF8 Original Articles Cell Biology Prognosis medicine.disease Immunohistochemistry Warburg effect Gene Expression Regulation Neoplastic Cell Transformation Neoplastic 030104 developmental biology 030220 oncology & carcinogenesis Cancer cell Cancer research Molecular Medicine Biomarker (medicine) Female Original Article business Carcinogenesis Glycolysis |
| Zdroj: | Journal of Cellular and Molecular Medicine |
| ISSN: | 1582-4934 1582-1838 |
| Popis: | Krüppel‐like transcription factor (KLF) family is involved in tumorigenesis in different types of cancer. However, the importance of KLF family in gastric cancer is unclear. Here, we examined KLF gene expression in five paired liver metastases and primary gastric cancer tissues by RT‐PCR, and immunohistochemistry was used to study KLF8 expression in 206 gastric cancer samples. The impact of KLF8 expression on glycolysis, an altered energy metabolism that characterizes cancer cells, was evaluated. KLF8 showed the highest up‐regulation in liver metastases compared with primary tumours among all KLF members. Higher KLF8 expression associated with larger tumour size (P |
| Databáze: | OpenAIRE |
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