Regulated Endocrine-Specific Protein-18, an Emerging Endocrine Protein in Physiology: A Literature Review
| Autor: | Mitchel C Perry, Sivarajan Kumarasamy, Ealla Atari, Pedro A. Jose |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Hypothalamo-Hypophyseal System medicine.medical_specialty Superior cervical ganglion Dopamine Phosphatase Nerve Tissue Proteins Protein tyrosine phosphatase Biology 03 medical and health sciences 0302 clinical medicine Endocrinology PTPRN Internal medicine Gastrins medicine Animals Humans Insulin Endocrine system Glucocorticoids Thyroid Parkinson Disease 030104 developmental biology medicine.anatomical_structure Cardiovascular Diseases Adrenal medulla Pancreas 030217 neurology & neurosurgery |
| Zdroj: | Endocrinology. 160:2093-2100 |
| ISSN: | 1945-7170 |
| DOI: | 10.1210/en.2019-00397 |
| Popis: | Regulated endocrine-specific protein-18 (RESP18), a novel 18-kDa protein, was first identified in neuroendocrine tissue. Subsequent studies showed that Resp18 is expressed in the adrenal medulla, brain, pancreas, pituitary, retina, stomach, superior cervical ganglion, testis, and thyroid and also circulates in the plasma. Resp18 has partial homology with the islet cell antigen 512, also known as protein tyrosine phosphatase, receptor type N (PTPRN), but does not have phosphatase activity. Resp18 might serve as an intracellular signal; however, its function is unclear. It is regulated by dopamine, glucocorticoids, and insulin. We recently reported that the targeted disruption of the Resp18 locus in Dahl salt-sensitive rats increased their blood pressure and caused renal injury. The aim of the present review was to provide a comprehensive summary of the reported data currently available, especially the expression and proposed organ-specific function of Resp18. |
| Databáze: | OpenAIRE |
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