Nanobody Conjugates for Targeted Cancer Therapy and Imaging
| Autor: | Xiao Ma, Yongsheng Yu, Wei Kang, Chuanfeng Ding, Xinyi Tong, Qian Zhou, Chuang Wu, Danni Zheng, Chuang Xue, Lun Yi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Diagnostic Imaging
0301 basic medicine Cancer Research Cancer therapy Antineoplastic Agents Review cancer imaging 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine Neoplasms Animals Humans Medicine therapeutic nanobodies RC254-282 Fluorescent Dyes antibody fragments Bioconjugation biology business.industry Immunogenicity Neoplasms. Tumors. Oncology. Including cancer and carcinogens Single-Domain Antibodies bioconjugations nanobodies Cancer treatment 030104 developmental biology Oncology 030220 oncology & carcinogenesis biology.protein Cancer research targeted caner treatment Antibody business In vivo pharmacokinetics Large size Conjugate |
| Zdroj: | Technology in Cancer Research & Treatment, Vol 20 (2021) Technology in Cancer Research & Treatment |
| ISSN: | 1533-0338 1533-0346 |
| Popis: | Conventional antibody-based targeted cancer therapy is one of the most promising avenues of successful cancer treatment, with the potential to reduce toxic side effects to healthy cells surrounding tumor cells. However, the full potential of antibodies is severely limited due to their large size, low stability, slow clearance, and high immunogenicity. Alternatively, recently discovered nanobodies, which are the smallest naturally occurring antigen-binding format, have shown great potential for addressing these limitations. Bioconjugation of nanobodies to functional groups such as toxins, enzymes, radionucleotides, and fluorophores can improve the efficacy and potency of nanobodies, enhance their in vivo pharmacokinetics, and expand the range of potential applications. Herein, we review the superior characteristics of nanobodies in comparison to conventional antibodies and provide insight into recent developments in nanobody conjugates for targeted cancer therapy and imaging. |
| Databáze: | OpenAIRE |
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