False-Positive Elevation of Creatine Kinase MB Mass Concentrations Caused by Macromolecules in a Patient who Underwent Nephrectomy for Renal Cell Carcinoma
| Autor: | Chong Rae Cho, Sollip Kim, Joon Seong Jeon, Tae Hyun Um |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Clinical Chemistry
Pathology medicine.medical_specialty biology business.industry medicine.drug_class Biochemistry (medical) Clinical Biochemistry Autoantibody General Medicine Monoclonal antibody Molecular biology Antigen Polyclonal antibodies Troponin I Monoclonal biology.protein Medicine Creatine kinase Antibody business Letter to the Editor |
| Zdroj: | Annals of Laboratory Medicine |
| ISSN: | 2234-3814 2234-3806 |
| DOI: | 10.3343/alm.2014.34.5.405 |
| Popis: | Creatine kinase MB isoform (CK-MB) is a biochemical marker that is used to evaluate patients with suspected acute myocardial infarction. Rapid immunoassays to measure CK-MB mass concentration use various monoclonal anti-CK-MB antibodies, and these have been reported to be highly sensitive, specific, and free of interference [1]. Here, we report the first case of a false-positive CK-MB result (as determined by a mass assay) from a patient who underwent nephrectomy for renal cell carcinoma. A 78-yr-old man was admitted to the Urology department of Ilsan Paik Hospital in Goyang, Korea, for partial nephrectomy for the treatment of renal cell carcinoma. He developed dyspnea and tachycardia at three days after the surgery. The electrocardiogram revealed atrial fibrillation. CK-MB mass concentrations, CK activity, and N-terminal B-type natriuretic peptide (NT-pro-BNP) levels increased to 10.44 µg/L (reference range |
| Databáze: | OpenAIRE |
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