Barrett's Oesophagus in an Achalasia Patient: Immunological Analysis and Comparison with a Group of Achalasia Patients
| Autor: | Braulio Martínez-Benítez, Enrique Coss-Adame, Samuel Torres-Landa, Edgar Alejandro-Medrano, Gonzalo Torres-Villalobos, Bárbara Ramos-Ávalos, Miguel A. Valdovinos, Janette Furuzawa-Carballeda |
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| Rok vydání: | 2016 |
| Předmět: |
History
medicine.medical_specialty Polymers and Plastics Achalasia Case Report Systemic inflammation Transplant Donors Gastroenterology digestive system Industrial and Manufacturing Engineering Pathogenesis 03 medical and health sciences 0302 clinical medicine Internal medicine medicine otorhinolaryngologic diseases Lower oesophageal sphincter Business and International Management lcsh:RC799-869 business.industry Gastrooesophageal junction Research needs medicine.disease digestive system diseases 030220 oncology & carcinogenesis Barrett's oesophagus 030211 gastroenterology & hepatology lcsh:Diseases of the digestive system. Gastroenterology medicine.symptom business |
| Zdroj: | Case Reports in Gastrointestinal Medicine Case Reports in Gastrointestinal Medicine, Vol 2016 (2016) |
| ISSN: | 2090-6528 |
| Popis: | The aim of the study was to characterize the presence of diverse CD4 and CD8 T cell subsets and regulatory cells in peripheral blood and lower oesophageal sphincter (LES) from a young patient with BE/achalasia without treatment versus achalasia group. In order to characterize the circulating cells in this patient, a cytometric analysis was performed. LES tissue was evaluated by double-immunostaining procedure. Five healthy blood donors, 5 type achalasia patients, and 5 oesophagus tissue samples (gastrooesophageal junction) from transplant donors were included as control groups. A conspicuous systemic inflammation was determined in BE/achalasia patient and achalasia versus healthy volunteer group. Nonetheless, a predominance of Th22, Th2, IFN-α-producing T cells, Tregs, Bregs, and pDCregs was observed in BE/achalasia patient versus achalasia group. A low percentage of Th1 subset in BE/achalasia versus achalasia group was determined. A noticeable increase in tissue of Th22, Th17, Th2, Tregs, Bregs, and pDCregs was observed in BE/achalasia versus achalasia group. Th1 subset was lower in the BE/achalasia patient versus achalasia group. This study suggests that inflammation is a possible factor in the pathogenesis of BE/achalasia. Further research needs to be performed to understand the specific cause of the correlation between BE and achalasia. |
| Databáze: | OpenAIRE |
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