Morphometric Analysis of Mast Cells in Tumor Predicts Recurrence of Hepatocellular Carcinoma After Liver Transplantation
| Autor: | Robert Eferl, Gerald Timelthaler, Matthias Pinter, Merima Herac, Markus Peck-Radosavljevic, Kaoru Tsuchiya, Nataliya Rohr-Udilova, Michael Trauner, Katharina Wöran, Tobias Meischl, W. Sieghart, Judith Stift, Martina Salzmann, Erika Jensen-Jarolim, Rolf Schulte-Hermann |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Carcinoma Hepatocellular medicine.medical_treatment RC799-869 Liver transplantation Milan criteria Gastroenterology Risk Assessment Immune system Predictive Value of Tests Internal medicine medicine Humans Mast Cells Postoperative Period Proportional Hazards Models Retrospective Studies Hepatology business.industry Proportional hazards model Hazard ratio Liver Neoplasms Original Articles Middle Aged Diseases of the digestive system. Gastroenterology Mast cell medicine.disease Prognosis Liver Transplantation medicine.anatomical_structure Treatment Outcome Hepatocellular carcinoma Cohort Female Original Article Neoplasm Recurrence Local business |
| Zdroj: | Hepatology Communications, Vol 5, Iss 11, Pp 1939-1952 (2021) Hepatology Communications |
| Popis: | Tumor‐infiltrating immune cells are relevant prognostic and immunotherapeutic targets in hepatocellular carcinoma (HCC). Mast cells play a key role in allergic response but may also be involved in anticancer immunity. Digital morphometric analysis of patient tissue sections has become increasingly available for clinical routine and provides unbiased quantitative data. Here, we apply morphometric analysis of mast cells to retrospectively evaluate their relevance for HCC recurrence in patients after orthotopic liver transplantation (OLT). A total of 173 patients underwent OLT for HCC at the Medical University of Vienna (21 women, 152 men; 55.2 ± 7.9 years; 74 beyond Milan criteria, 49 beyond up‐to‐7 criteria for liver transplantation). Tissue arrays from tumors and corresponding surrounding tissues were immunohistochemically stained for mast cell tryptase. Mast cells were quantified by digital tissue morphometric analysis and correlated with HCC recurrence. Mast cells were detected in 93% of HCC tumors and in all available surrounding liver tissues. Tumor tissues revealed lower mast cell density than corresponding surrounding tissues (P We applied digital morphometric analysis to evaluate microscopic tissue images of mast cells in tumors and surrounding tissues of hepatocellular carcinoma patients who underwent liver transplantation. We found that intratumoral mast cell density is an independent prognostic factor of HCC recurrence. Mast cells were decreased in tumors as compared to surrounding tissues; lack of mast cells indicated higher tumor recurrence risk. To our best knowledge, this is the first report on the link between hepatic mast cells and HCC recurrence after transplantation. These data also suggest that hepatic mast cells might be implicated in anti‐tumor immunity in HCC. |
| Databáze: | OpenAIRE |
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