Association between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease: A Single-Center Clinical Study

Autor:	Zhenpeng Huang, Chaoqun Zhang, Ou Cai, Ming Li, Fengbo Xi, Shiyun Tan
Rok vydání:	2018
Předmět:	medicine.medical_specialty Helicobacter pylori infection Article Subject Prevalence Single Center digestive system Gastroenterology 13C urea breath test Clinical study 03 medical and health sciences 0302 clinical medicine Internal medicine Nonalcoholic fatty liver disease Medicine lcsh:RC799-869 Risk factor Hepatology biology business.industry nutritional and metabolic diseases Helicobacter pylori medicine.disease biology.organism_classification digestive system diseases 030220 oncology & carcinogenesis lcsh:Diseases of the digestive system. Gastroenterology 030211 gastroenterology & hepatology business Research Article
Zdroj:	Gastroenterology Research and Practice, Vol 2018 (2018) Gastroenterology Research and Practice
ISSN:	1687-630X 1687-6121
DOI:	10.1155/2018/8040262
Popis:	Objective. To investigate the association between Helicobacter pylori (H. pylori) infection and nonalcoholic fatty liver disease (NAFLD). Methods. Data from 2051 participants who underwent 13C urea breath test and abdominal ultrasound examinations was collected. Participants were allocated to NAFLD risk group and NAFLD nonrisk group based on definite risk factors for NAFLD. The relationship between H. pylori infection and NAFLD was analyzed. Results. No significant difference was found between rates of H. pylori infection and NAFLD using the chi-square test (P=0.30) or regression analysis (P=0.70). There was no significant difference between rates of H. pylori infection with and without NAFLD (P=0.47) in the NAFLD risk group or in the NAFLD nonrisk group (P=0.59). There was no significant difference between rates of H. pylori infection in men (P=0.69) and in women (P=0.27) or in participants aged 18–40 years (P=0.43), 41–65 years (P=0.14), and ≥66 years (P=0.66) with and without NAFLD in the NAFLD risk group or between the same sex or age groups (P=0.82, P=0.66, P=0.24, P=0.53, and P=1.00, resp.) in the NAFLD nonrisk group. Conclusions. H. pylori infection does not appear to increase the NAFLD prevalence rate or to be associated with, or a risk factor for, NAFLD.
Databáze:	OpenAIRE
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