Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota
| Autor: | Bernhard Hube, Sarah Höfs, Selene Mogavero |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Virulence Factors 030106 microbiology Virulence Adaptive Immunity Applied Microbiology and Biotechnology Microbiology Proinflammatory cytokine 03 medical and health sciences Immune system Candida albicans medicine Animals Humans Cell damage Immune Evasion biology Host (biology) Candidiasis Biofilm General Medicine biology.organism_classification medicine.disease Immunity Innate Corpus albicans 030104 developmental biology Host-Pathogen Interactions Immunology |
| Zdroj: | Journal of Microbiology. 54:149-169 |
| ISSN: | 1976-3794 1225-8873 |
| DOI: | 10.1007/s12275-016-5514-0 |
| Popis: | The interaction between Candida albicans and its host cells is characterized by a complex interplay between the expression of fungal virulence factors, which results in adherence, invasion and cell damage, and the host immune system, which responds by secreting proinflammatory cytokines, activating antimicrobial activities and killing the fungal pathogen. In this review we describe this interplay by taking a closer look at how C. albicans pathogenicity is induced and executed, how the host responds in order to prevent and clear an infection, and which mechanisms C. albicans has evolved to bypass these immune responses to avoid clearance. Furthermore, we review studies that show how the presence of other microorganisms affects this interplay. |
| Databáze: | OpenAIRE |
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