Severe impairment of ventricular compliance accounts for advanced age-associated hemodynamic dysfunction in rats

Autor: Benoît Tavernier, Joël de Leiris, Bruno Riou, Bernard Swynghedauw, Sandrine Rozenberg, Christine Le Page, Sophie Besse, François Boucher
Přispěvatelé: Laboratoire de Pharmacologie - EA 1046, Université de Lille, Laboratoire d'Anesthésiologie, Université Pierre et Marie Curie - Paris 6 (UPMC), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Laboratoire CRRET, EAC/CNRS-7149, Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Laboratoire Nutrition, Vieillissement et Maladies Cardiovasculaires, Université Joseph Fourier - Grenoble 1 (UJF), Sorbonne Université (SU), Courty, José, Croissance cellulaire, réparation et régénération tissulaires (CRRET), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)
Jazyk: angličtina
Rok vydání: 2006
Předmět:
Male
Aging
medicine.medical_specialty
Myofilament
Heart Ventricles
[SDV]Life Sciences [q-bio]
Diastole
Hemodynamics
Blood Pressure
Biochemistry
Ventricular Dysfunction
Left
Endocrinology
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Heart Rate
Internal medicine
Ventricular Pressure
Genetics
medicine
Animals
Rats
Wistar
Molecular Biology
Papillary muscle
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology
business.industry
Myocardium
Body Weight
Organ Size
Cell Biology
Papillary Muscles
medicine.disease
Actin cytoskeleton
Rats
[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Actin Cytoskeleton
Blood pressure
medicine.anatomical_structure
Heart failure
Models
Animal
Cardiology
Ventricular pressure
Calcium
Hypertrophy
Left Ventricular
business
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Zdroj: Experimental Gerontology
Experimental Gerontology, 2006, 41 (3), pp.289-295. ⟨10.1016/j.exger.2005.11.009⟩
Experimental Gerontology, Elsevier, 2006, 41 (3), pp.289-295
ISSN: 0531-5565
Popis: International audience; Advanced aging is associated with hemodynamic dysfunction in rats as in humans. The aim of this study was to assess the mechanisms of development of left ventricular (LV) dysfunction in the rat model of aging. In vivo hemodynamics and ex vivo LV papillary muscle mechanics, myofilaments sensitivity to calcium in skinned fibers and pressure/volume curves in isolated perfused hearts were performed in 3, 24 and 28 month old (mo) male Wistar rats. Hemodynamic dysfunction occurs in 28 mo rats and is characterized by both a systolic and diastolic dysfunction and a LV hypertrophy (+34.7% of LV weight). In papillary muscle, normalized active developed force and myofilament sensitivity to calcium were unchanged between 24 and 28 months of age. In contrast, both resting force/total force ratio in papillary muscle and the slope of the pressure/volume curves in isolated heart are increased between 3 and 24 mo but also between 24 and 28 mo, indicating a progression of the impairment of both papillary muscle stiffness and LV compliance in advanced aging. Hemodynamic dysfunction occurring at advanced age, i.e. 28 mo in rats mainly results from impairment of ventricular compliance resulting from fibrosis.
Databáze: OpenAIRE
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