Effects of long-term exposure to tenofovir disoproxil fumarate-containing antiretroviral therapy on renal function in HIV-positive Chinese patients
| Autor: | Yan Wang, Yuan-Hong He, Tong-Tong Yang, Sheng-Hua He, Zhong-Hui Zhou, Dong-Mei Yan, Qing Tan, Xia Zhao, Huan-Xia Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) medicine.medical_specialty Tenofovir Anti-HIV Agents 030106 microbiology lcsh:QR1-502 Renal function HIV Infections Kidney Gastroenterology lcsh:Microbiology Nephrotoxicity Kidney Tubules Proximal Young Adult 03 medical and health sciences Hepatitis B Chronic 0302 clinical medicine Asian People Internal medicine medicine Humans Immunology and Allergy Renal Insufficiency 030212 general & internal medicine Retrospective Studies Proteinuria General Immunology and Microbiology business.industry Incidence (epidemiology) Lamivudine General Medicine Middle Aged Antiretroviral therapy Regimen Infectious Diseases Female medicine.symptom business Glomerular Filtration Rate medicine.drug |
| Zdroj: | Journal of Microbiology, Immunology and Infection, Vol 52, Iss 5, Pp 710-719 (2019) |
| ISSN: | 1684-1182 |
| Popis: | Background: The regimen containing tenofovir disoproxil fumarate (TDF)+lamivudine or emtricitabine + efavirenz remains the recommended first-line antiretroviral therapy (ART) by the WHO. Limited studies, however, have been conducted on the incidence of renal impairment among Chinese patients with long-term exposure to TDF-containing ART regimens. Methods: We retrospectively analyzed 269 eligible patients who had no comorbidities and received TDF-containing ART from July 2014 to April 2015. TDF-related renal impairment was defined as a decrease of eGFR by >25% from baseline or eGFR 10 mL/min/1.73 m2 from baseline. Results: 97.0% of study patients were male (median age 29, eGFR 124.0 ml/min/1.73 m2). After 168-week of ART, renal impairment occurred in 7 patients (2.7%). The incidence of decreased renal function was significantly higher at Week 168 compared with that observed at Week 12 (24.8% vs 3.7%, p |
| Databáze: | OpenAIRE |
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