MR spectroscopy and diffusion tensor imaging of the brain in Sjogren-Larsson syndrome
| Autor: | Paul E. Sijens, Matthijs Oudkerk, Jan Hendrik Potze, van FrancJan Spronsen, Maartje Boon, Henriëtte E. Westerlaan, Roelineke J. Lunsing, de Jan Groot |
|---|---|
| Přispěvatelé: | University of Groningen, Faculteit Medische Wetenschappen/UMCG, Center for Liver, Digestive and Metabolic Diseases (CLDM) |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
In vivo magnetic resonance spectroscopy
Endocrinology Diabetes and Metabolism Biochemistry Cerebral white matter White matter chemistry.chemical_compound Lateral ventricles Endocrinology Nuclear magnetic resonance Pregnancy Fractional anisotropy Magnetic resonance spectroscopy Genetics medicine Choline Effective diffusion coefficient Humans FATTY ALDEHYDE DEHYDROGENASE Molecular Biology Brain Mapping Sjögren–Larsson syndrome Brain MULTIPLE-SCLEROSIS Lipid medicine.disease Sjogren-Larsson syndrome medicine.anatomical_structure Diffusion Magnetic Resonance Imaging Diffusion tensor imaging chemistry nervous system Child Preschool Anisotropy Female CULTURED FIBROBLASTS Diffusion MRI |
| Zdroj: | Molecular Genetics and Metabolism, 98(4), 367-371. ACADEMIC PRESS INC ELSEVIER SCIENCE |
| ISSN: | 1096-7192 |
| Popis: | Diffusion tensor imaging (DTI) is reported for the first time in a patient with Sjogren-Larsson syndrome, an autosomal recessive neurocutaneous disorder. Magnetic resonance spectroscopy (MRS) revealed normal levels of choline, creatine and N-acetyl aspartate (NAA) and the characteristic lipid signals in the white matter brain tissue. Conventional MRI showed increased signal intensity around the lateral ventricles indicating abnormal myelination. DTI revealed normal apparent diffusion coefficient (ADC) values, but reduced fractional anisotropy (FA) in the white matter. After co-registration of the parameters obtained with DTI with the results of MRS (36 voxels), significant correlations were obtained of lipid content with FA (r = 0.81), ADC (r = -0.62), choline (r = 0.51), and NAA (r = 0.44) (P |
| Databáze: | OpenAIRE |
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