The miR-34 family and its clinical significance in ovarian cancer
| Autor: | S Wenzel, H Welponer, Verena Wieser, Susanne Sprung, Hubert Hackl, H Fiegl, I Tsibulak, Alain G. Zeimet, Christian Marth, Giridhar Shivalingaiah, C Degasper |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology p53 medicine.medical_specialty medicine.disease_cause survival 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Internal medicine Medicine Clinical significance Progression-free survival Inverse correlation business.industry miR-34 medicine.disease Serous fluid 030104 developmental biology medicine.anatomical_structure ovarian cancer 030220 oncology & carcinogenesis business Carcinogenesis Ovarian cancer carcinogenesis Fallopian tube Research Paper |
| Zdroj: | Journal of Cancer |
| ISSN: | 1837-9664 |
| Popis: | The tumor suppressor miR-34 family is transcriptionally induced by p53. Clinical significance of the various miR-34 family members has not been studied in ovarian cancer. In 228 ovarian cancers and in 19 non-neoplastic fallopian tube samples we analysed miR-34 a/b/c expression in relation to clinicopathological characteristics and clinical outcome. We found significantly lower levels of miR-34 a/b/c in ovarian cancers as compared to control-tissues (P=0.002, P |
| Databáze: | OpenAIRE |
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