Epidemiological and molecular analysis of circulating fowl adenoviruses and emerging of serotypes 1, 3, and 8b in Egypt
| Autor: | Wafaa M. M. Hassan, Ahmed Abd-El Halim, Naglaa A. Hagag, Mahmoud Said, Momtaz A Shahien, Ahmed M. Erfan, Abd El-Satar Arafa, Mohamed E. El Zowalaty, Amany Adel, Mahmoud Samir |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Serotype
Adenoviruses Science (General) Fowl adenovirus Epidemiology Fowl In silico viruses Hypervariable Microbiology Virus Epitope Q1-390 Antigen Loop1 Sequence medicine Hepatitis Emerging H1-99 Multidisciplinary biology Molecular analysis biology.organism_classification medicine.disease Virology Hypervariable region Social sciences (General) Mikrobiologi Includion body Hepatitis Research Article |
| Zdroj: | Heliyon, Vol 7, Iss 12, Pp e08366-(2021) Heliyon |
| ISSN: | 2405-8440 |
| Popis: | Fowl adenoviruses (FAdVs) are a large group of viruses of different serotypes. They are responsible for inclusion body hepatitis, adenoviral gizzard erosion, and hepatitis hydropericardium syndrome. The present study presents a comprehensive overview of FAdVs in Egypt, with a focus on the epidemiological features of virus serotypes across the country. We conducted molecular investigation of multiple FAdV species based on the genetic signature of hypervariable regions 1–4 in the loop1 (L1) region of the hexon gene. Epidemiologically, the Nile Delta governorates showed high positivity of FAdVs, which were more commonly found in broilers than in layers. Genetically, species D and serotype 8a/E dominated, and the findings also revealed the emergence of new FAdV serotypes 1, 3, and 8b. The comparative analysis of hypervariable regions in the L1 region of the hexon gene revealed variables specific to each virus serotype. In silico predictions of L1 region revealed variations in the molecular structure and predicted the antigenic epitopes which may affect the cross-antigenicity between the different FAdV species and serotypes. Fowl adenovirus, Loop1, HVRs, Egypt. |
| Databáze: | OpenAIRE |
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