Genetic Diversity and the Efficacy of Purifying Selection across Plant and Animal Species
| Autor: | Jun Chen, Martin Lascoux, Sylvain Glémin |
|---|---|
| Přispěvatelé: | Department of Ecology and Genetics [Uppsala] (EBC), Uppsala University, Evolutionary Biology Centre (EBC), Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0106 biological sciences
0301 basic medicine Nonsynonymous substitution MESH: Genome Plant Mutation rate MESH: Selection Genetic 01 natural sciences Nucleotide diversity Effective population size MESH: Genetic Fitness Purifying selection MESH: Animals MESH: Genetic Variation MESH: Models Genetic MESH: Phylogeny Phylogeny MESH: Evolution Molecular Genome [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] Biological Evolution MESH: Silent Mutation Distribution of fitness effects Genome Plant MESH: Mutation MESH: Population Density MESH: Biological Evolution Biology 010603 evolutionary biology Life history theory Evolution Molecular [SDV.GEN.GPL]Life Sciences [q-bio]/Genetics/Plants genetics 03 medical and health sciences MESH: Polymorphism Genetic Genetics Animals MESH: Genome Selection Genetic Nearly neutral theory Molecular Biology Silent Mutation Ecology Evolution Behavior and Systematics Population Density Genetic diversity Polymorphism Genetic Models Genetic business.industry Genetic Variation Life history traits 15. Life on land Mating system Biotechnology [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics 030104 developmental biology Evolutionary biology Mutation Nearly neutral theory of molecular evolution Genetic Fitness business |
| Zdroj: | Molecular Biology and Evolution Molecular Biology and Evolution, Oxford University Press (OUP), 2017, 34 (6), pp.1417-1428. ⟨10.1093/molbev/msx088⟩ Molecular Biology and Evolution, 2017, 34 (6), pp.1417-1428. ⟨10.1093/molbev/msx088⟩ |
| ISSN: | 0737-4038 1537-1719 |
| DOI: | 10.1093/molbev/msx088⟩ |
| Popis: | International audience; A central question in evolutionary biology is why some species have more genetic diversity than others and a no less important question is why selection efficacy varies among species. Although these questions have started to be tackled in animals, they have not been addressed to the same extent in plants. Here, we estimated nucleotide diversity at synonymous, πS, and nonsynonymous sites, πN, and a measure of the efficacy of selection, the ratio πN/πS, in 34 animal and 28 plant species using full genome data. We then evaluated the relationship of nucleotide diversity and selection efficacy with effective population size, the distribution of fitness effect and life history traits. In animals, our data confirm that longevity and propagule size are the variables that best explain the variation in πS among species. In plants longevity also plays a major role as well as mating system. As predicted by the nearly neutral theory of molecular evolution, the log of πN/πS decreased linearly with the log of πS but the slope was weaker in plants than in animals. This appears to be due to a higher mutation rate in long lived plants, and the difference disappears when πS is rescaled by the mutation rate. Differences in the distribution of fitness effect of new mutations also contributed to variation in πN/πS among species. |
| Databáze: | OpenAIRE |
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