The diverse role of optineurin in pathogenesis of disease
| Autor: | Qinjie Weng, Jincheng Wang, Qingyi Guo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cell Cycle Proteins Disease Biology medicine.disease_cause Biochemistry Communicable Diseases Pathogenesis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Neoplasms medicine Animals Humans Amyotrophic lateral sclerosis Optineurin Pharmacology Mutation Autophagy Membrane Transport Proteins NF-κB Neurodegenerative Diseases medicine.disease Protein Transport 030104 developmental biology chemistry 030220 oncology & carcinogenesis Signal transduction Neuroscience Protein Binding Signal Transduction |
| Zdroj: | Biochemical pharmacology. 180 |
| ISSN: | 1873-2968 |
| Popis: | Optineurin is a widely expressed protein that possesses multiple functions. Growing evidence suggests that mutation or dysregulation of optineurin can cause several neurodegenerative diseases, including amyotrophic lateral sclerosis, primary open-angle glaucoma, and Huntington's disease, as well as inflammatory digestive disorders such as Crohn's disease. Optineurin engages in vesicular trafficking, receptor regulation, immune reactions, autophagy, and distinct signaling pathways including nuclear factor kappa beta, by which optineurin contributes to cellular death and related diseases, indicating its potential as a therapeutic target. In this review, we discuss the major functions and signaling pathways of optineurin. Furthermore, we illustrate the influence of optineurin mutation or dysregulation to region-specific pathogenesis as well as potential applications of optineurin in therapeutic strategies. |
| Databáze: | OpenAIRE |
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