Erythrocyte Mean Corpuscular Volume as a Surrogate Marker for 6-Thioguanine Nucleotide Concentration Monitoring in Patients with Inflammatory Bowel Disease Treated with Azathioprine or 6-Mercaptopurine

Autor: James J. Lipsky, William J. Sandborn, Philip W. Lowry, Curtis L. Franklin, William J. Tremaine, Carlton W. Thomas, Dennis C. Mays, Amy L. Weaver, Gennett M. Myhre
Rok vydání: 2003
Předmět:
Adult
Erythrocyte Indices
Male
congenital
hereditary
and neonatal diseases and abnormalities
medicine.medical_specialty
Pathology
Erythrocytes
Adolescent
Endpoint Determination
Azathioprine
Severity of Illness Index
Inflammatory bowel disease
Gastroenterology
Leukocyte Count
Surveys and Questionnaires
hemic and lymphatic diseases
Internal medicine
medicine
Humans
Immunology and Allergy
Erythrocyte Mean Corpuscular Volume
Mean corpuscular volume
Aged
Whole blood
Aged
80 and over
Leukopenia
medicine.diagnostic_test
Mercaptopurine
business.industry
Surrogate endpoint
Middle Aged
Thionucleotides
Inflammatory Bowel Diseases
medicine.disease
Guanine Nucleotides
Treatment Outcome
Female
medicine.symptom
business
Biomarkers
Immunosuppressive Agents
circulatory and respiratory physiology
medicine.drug
Zdroj: Inflammatory Bowel Diseases. 9:237-245
ISSN: 1078-0998
DOI: 10.1097/00054725-200307000-00004
Popis: Mean corpuscular volume may correlate with erythrocyte 6-thioguanine nucleotide concentrations in patients treated with azathioprine and 6-mercaptourine. We conducted a study of 166 patients with inflammatory bowel disease treated with azathioprine or 6-mercaptopurine to determine the relationship between mean corpuscular volume and erythrocyte 6-thioguanine nucleotide concentrations, disease activity as measured by the Inflammatory Bowel Disease Questionnaire (active disease170, remission170), and leukopenia. Blood was submitted for mean corpuscular volume, whole blood 6-thioguanine nucleotide concentration, and leukocyte count. The mean +/- SD mean corpuscular volume during treatment was 94.7 +/- 6.6 fL and the mean +/- SD change in mean corpuscular volume was 7.5 +/- 6.3 fL. There were significant correlations between mean corpuscular volume and erythrocyte 6-thioguanine nucleotide concentration (r(s) = 0.33, p0.001) and between change from baseline in mean corpuscular volume and erythrocyte 6-thioguanine nucleotide concentration (r(s) = 0.26, p = 0.001). There was no correlation between Inflammatory Bowel Disease Questionnaire scores and mean corpuscular volume values (r(s) = 0.01, p = 0.94). The mean corpuscular volume values in 55 patients with active disease and 111 patients in remission were similar (95.1 vs. 94.5 fL, p = 0.57). There was a weak negative correlation between the mean corpuscular volume and the leukocyte count, (r(s) = -0.18, p = 0.022). In patients with inflammatory bowel disease treated with azathioprine or 6-mercaptopurine, mean corpuscular volume and change from baseline in mean corpuscular volume correlated with erythrocyte 6-thioguanine nucleotide concentrations and negatively with leukocyte counts, but did not correlate with disease activity as measured by the Inflammatory Bowel Disease Questionnaire. Measurement of mean corpuscular volume is a simple and inexpensive alternative to measurement of 6-thioguanine nucleotide concentrations in patients treated with azathioprine or 6-mercaptopurine.
Databáze: OpenAIRE
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