Invasive maxillary aspergillosis in a patient with systemic lupus erythematosus: Case report
| Autor: | Siti Isya Wahdini, Aditya Wicaksana, Muhammad Rosadi Seswandhana, Ishandono Dachlan, Aditya Rifqi Fauzi, Franciscus Wihan Pradana, Muhammad Bakhrul Lutfianto, Nurardhilah Vityadewi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Surgical results
medicine.medical_specialty Palate biopsy medicine.medical_treatment Case Report ENT ear nose and throat Aspergillosis GMS Grocott-Gomori's Methenamine Silver SLE systemic lupus erythematosus 03 medical and health sciences High morbidity CT scan computed tomography 0302 clinical medicine Systemic lupus erythematosus medicine Plastic reconstructive surgery ANA antinuclear antibodies Palatal defect Debridement business.industry Surgical debridement IA Invasive aspergillosis anti-dsDNA anti-double stranded DNA General Medicine FRS fungal rhinosinusitis medicine.disease PAS Periodic Acid-Schiff Surgery 030220 oncology & carcinogenesis Maxillary defect Invasive aspergillosis 030211 gastroenterology & hepatology business Oral cyclophosphamide MRI magnetic resonance imaging Fluconazole medicine.drug |
| Zdroj: | Annals of Medicine and Surgery |
| ISSN: | 2049-0801 |
| Popis: | Introduction Invasive aspergillosis (IA) is a fungal infection caused by Aspergillus species (spp.). Aspergillosis is the most common source of opportunistic fungal infection in humans. IA can cause serious complications related to high morbidity and mortality in immunocompromised patients. Presentation of case We report a case of a 22-year-old female with a chief complaint of having a hole in the roof of her mouth. She was diagnosed with SLE in 2009. She had been consuming oral methylprednisolone ever since. In 2018, she experienced worsened symptoms and was hospitalized. She experienced swelling and bleeding of her gums and some of her teeth becoming loose and falling out, and then developing a hole in the roof of her mouth. Subsequently, she was treated with oral cyclophosphamide, oral mycophenolate sodium, and oral fluconazole. She was asked to stop taking oral methylprednisolone. In 2019, the palate biopsy was performed and showed Aspergillus spp. invading the palate. Afterward, the patient was referred to our clinic for defect closure. The patient was operated on for debridement and reconstruction of the defect. There was no recurrence of the defect or complications observed in the follow-up. The patient was satisfied with the surgical results. Discussion IA is a destructive and potentially harmful opportunistic fungal infection and treatments with surgical interventions should be well-thought-out in immunocompromised patients. Conclusion The management of IA are controlling any underlying diseases and surgical debridement or necrotomy. Generally, antifungal therapy and prompt surgical intervention are successful in managing invasive aspergillosis. Highlights • IA can cause serious complications, especially immunocompromised patients. • The management can vary from pharmacological therapy to surgical intervention. • Antifungal therapy and prompt surgical intervention are successful in managing invasive aspergillosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|