The presence of the HLA class. II allele DPB1*0501 in ethnic Thais correlates with an enhanced vaccine-induced antibody response to a malaria sporozoite antigen
| Autor: | Daniel M. Gordon, H. K. Webster, Ekaraj Rungruang, Somboon Lekmak, Monchan Sirikong, Panpiman Longta, Dasnayanee Chandanayingyong, H. A. E. Stephens, Rapeepun Vangseratthana, Arthur Brown |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male HLA-DP Antigens Molecular Sequence Data Immunology Antibodies Protozoan HLA-DP Human leukocyte antigen Biology Antigen Malaria Vaccines Animals Humans Immunology and Allergy Allele Allele frequency HLA-DP beta-Chains Base Sequence Plasmodium falciparum Middle Aged Thailand biology.organism_classification Virology Vaccination biology.protein Immunization Antibody |
| Zdroj: | European Journal of Immunology. 25:3142-3147 |
| ISSN: | 1521-4141 0014-2980 |
| Popis: | In this study, we examined the correlation between the frequency of allelic variants of the class II human leukocyte antigen (HLA) DR, DQ and DP gene loci and the quantitative humoral immune response observed in 71 Thai volunteers, subsequent to vaccination with a conjugated subunit vaccine. This vaccine was designed to induce antibodies directed against the immunodominant repeat region of the Plasmodium falciparum circumsporozoite (CS) protein. The presence of the DPB1*0501, a relatively common allele in Asian populations, was found to be associated with high vaccine-induced CS repeat-specific antibody responses in the volunteers. Given the increasing focus on the use of subunit vaccines in the control of infectious diseases, consideration of the influence of class II allele frequencies in ethnically diverse recipient populations may be important. |
| Databáze: | OpenAIRE |
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