Inhibitory effect of curcumin on testosterone induced benign prostatic hyperplasia rat model

Autor: Sang Hyub Lee, Hae Jeong Park, Hosik Seok, Young Ock Kim, Joo-Ho Chung, Sang Yeol Song, Jooil Yi, Byung-Cheol Lee, Sang Wook Kang, Su Kang Kim, Hye Sook Jeon
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Blood Glucose
Vascular Endothelial Growth Factor A
Male
Prostatic Hyperplasia
Pharmacology
urologic and male genital diseases
chemistry.chemical_compound
Prostate
Testosterone
Insulin-Like Growth Factor I
Anti-Inflammatory Agents
Non-Steroidal
General Medicine
Hyperplasia
Immunohistochemistry
medicine.anatomical_structure
Dihydrotestosterone
BPH
Finasteride
medicine.drug
Research Article
medicine.medical_specialty
Curcumin
medicine.drug_class
Urology
Rat model
Blotting
Western
Transforming Growth Factor beta1
Text mining
Internal medicine
medicine
Animals
Humans
Rats
Wistar
Inhibitory effect
Analysis of Variance
Benign prostatic hyperplasia
business.industry
urogenital system
Body Weight
Testosterone (patch)
Androgen
medicine.disease
Rats
Disease Models
Animal
Endocrinology
chemistry
Complementary and alternative medicine
business
Biomarkers
Zdroj: BMC Complementary and Alternative Medicine
ISSN: 1472-6882
Popis: Background Benign prostatic hyperplasia (BPH) is one of the common male diseases, which is provoked by dihydrotestosterone (DHT) and androgen signals. Several studies showed that curcumin has various effects of prevention and treatment to diseases. We investigated whether curcumin may repress the development of BPH in male Wistar rats. Methods Seven weeks male Wistar rats were and divided into 4 groups (normal group, BPH group, finasteride group, curcumin group; n = 8 for each group). In order to induce BPH in rats, rats were castrated and testosterone was injected subcutaneously everyday (s.c., 20 mg/kg). Rats in the curcumin group were treated 50 mg/kg, administered orally for 4 weeks. After 4 weeks, all rats were sacrificed and their prostate and serum were analyzed. Results Compared to the finasteride group as positive group, the curcumin group showed similarly protective effect on BPH in histopathologic morphology, prostate volume. Results of immunohistochemistry and western-blot showed decreased expressions of VEGF, TGF-ß1, and IGF1 were also decreased in the curcumin group. Conclusions These results suggested that curcumin inhibited the development of BPH and might a useful herbal treatment or functional food for BPH.
Databáze: OpenAIRE
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